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Poglut2 protein O-glucosyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316370, updated on 30-Mar-2024

Summary

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Official Symbol
Poglut2provided by RGD
Official Full Name
protein O-glucosyltransferase 2provided by RGD
Primary source
RGD:1304684
See related
Ensembl:ENSRNOG00000011740 AllianceGenome:RGD:1304684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kdelc1
Summary
Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine. Predicted to be located in cytosol; endoplasmic reticulum lumen; and nucleoplasm. Predicted to be active in endomembrane system. Orthologous to human POGLUT2 (protein O-glucosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 91.6), Adrenal (RPKM 77.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Poglut2 in Genome Data Viewer
Location:
9q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (53748484..53801453, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (46256388..46268714, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (50872492..50884596, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 168 Neighboring gene testis expressed 30 Neighboring gene basic, immunoglobulin-like variable motif containing Neighboring gene ERCC excision repair 5, endonuclease Neighboring gene methyltransferase like 21C-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search. Kimata Y, et al. Gene, 2000 Dec 31. PMID 11167020
  2. Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling. Takeuchi H, et al. Proc Natl Acad Sci U S A, 2018 Sep 4. PMID 30127001, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC189327

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP-xylosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein O-glucosyltransferase 2
Names
KDEL (Lys-Asp-Glu-Leu) containing 1
KDEL motif containing 1
KDEL motif-containing protein 1
NP_001264157.1
XP_063123236.1
XP_063123237.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277228.1 → NP_001264157.1  protein O-glucosyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_001264157.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AI78, A0A9K3Y6Q7, B5DFA5, F7FHZ5
    Related
    ENSRNOP00000016285.6, ENSRNOT00000016285.7
    Conserved Domains (3) summary
    smart00557
    Location:29 → 129
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:28 → 127
    Filamin; Filamin/ABP280 repeat
    pfam05686
    Location:151 → 484
    Glyco_transf_90; Glycosyl transferase family 90

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    53748484..53801453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267167.1 → XP_063123237.1  protein O-glucosyltransferase 2 isoform X1

  2. XM_063267166.1 → XP_063123236.1  protein O-glucosyltransferase 2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108217.1: Suppressed sequence

    Description
    NM_001108217.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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