Aox4 aldehyde oxidase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aox4provided by RGD
Official Full Name: aldehyde oxidase 4provided by RGD
Primary source: RGD:1311975
See related: Ensembl:ENSRNOG00000014555 AllianceGenome:RGD:1311975
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aoh2; Aa2-245; RGD1311975
Summary: Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 5.5), Lung (RPKM 4.1) and 5 other tissues See more
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Genomic context

Location:: 9q31

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (67255437..67312364)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (59761238..59818169)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (65110330..65167188)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables aldehyde oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde oxidase activity	IEA Inferred from Electronic Annotation more info
enables aldehyde oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables molybdenum ion binding	IEA Inferred from Electronic Annotation more info
enables molybdopterin cofactor binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in xenobiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aldehyde oxidase 4

Names: aldehyde oxidase homolog 2; azaheterocycle hydroxylase 4; retinal oxidase

NP_001008523.2

EC 1.2.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008523.2 → NP_001008523.2 aldehyde oxidase 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q5QE79

UniProtKB/TrEMBL

A0A0G2QC16

Related

ENSRNOP00000035377.6, ENSRNOT00000033068.6

Conserved Domains (1) summary

TIGR02969
Location:7 → 1332

mam_aldehyde_ox; aldehyde oxidase