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Fbxl17 F-box and leucine-rich repeat protein 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316663, updated on 6-Jun-2024

Summary

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Official Symbol
Fbxl17provided by RGD
Official Full Name
F-box and leucine-rich repeat protein 17provided by RGD
Primary source
RGD:1309773
See related
Ensembl:ENSRNOG00000013875 AllianceGenome:RGD:1309773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in protein polyubiquitination; proteolysis involved in cellular protein catabolic process; and regulation of smoothened signaling pathway. Predicted to be located in nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXL17 (F-box and leucine rich repeat protein 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 210.8), Kidney (RPKM 178.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxl17 in Genome Data Viewer
Location:
9q37
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (110227609..110666184, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (102780573..103206978, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (110515558..110936631, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480427 Neighboring gene uncharacterized LOC120094760 Neighboring gene tubulin alpha-1B chain-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480616 Neighboring gene uncharacterized LOC134480614 Neighboring gene uncharacterized LOC134480615 Neighboring gene uncharacterized LOC120094810

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dimerization quality control ensures neuronal development and survival. Mena EL, et al. Science, 2018 Oct 12. PMID 30190310
  2. SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. Raducu M, et al. EMBO J, 2016 Jul 1. PMID 27234298, Free PMC Article
  3. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. Tan MK, et al. Mol Cell, 2013 Oct 10. PMID 24035498, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108235.2 → NP_001101705.2  F-box/LRR-repeat protein 17

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    D3ZVD0
    Related
    ENSRNOP00000063692.2, ENSRNOT00000064431.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    110227609..110666184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083777.2 → XP_038939705.1  F-box/LRR-repeat protein 17 isoform X1

    Conserved Domains (3) summary
    cd09293
    Location:406 → 568
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:357 → 382
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:316 → 361
    F-box-like

  2. XM_063267332.1 → XP_063123402.1  F-box/LRR-repeat protein 17 isoform X6

    UniProtKB/TrEMBL
    A6JRA1

  3. XM_039083781.2 → XP_038939709.1  F-box/LRR-repeat protein 17 isoform X5

    Conserved Domains (3) summary
    cd09293
    Location:406 → 580
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:357 → 382
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:316 → 361
    F-box-like

  4. XM_039083778.2 → XP_038939706.1  F-box/LRR-repeat protein 17 isoform X2

    Conserved Domains (3) summary
    cd09293
    Location:406 → 568
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:357 → 382
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:316 → 361
    F-box-like

  5. XM_063267329.1 → XP_063123399.1  F-box/LRR-repeat protein 17 isoform X2

  6. XM_063267330.1 → XP_063123400.1  F-box/LRR-repeat protein 17 isoform X3

  7. XM_063267331.1 → XP_063123401.1  F-box/LRR-repeat protein 17 isoform X4

  8. XM_039083780.2 → XP_038939708.1  F-box/LRR-repeat protein 17 isoform X4

    Conserved Domains (3) summary
    cd09293
    Location:406 → 568
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:357 → 382
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:316 → 361
    F-box-like
Nucleotide Protein Strain
Heading Accession and Version

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