snz snazarus [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: snzprovided by FlyBase
Official Full Name: snazarusprovided by FlyBase
Primary source: FLYBASE:FBgn0029976
Locus tag: Dmel_CG1514
See related: AllianceGenome:FB:FBgn0029976
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1514; Dmel\CG1514; DmSNX25; Snz; SNZ
Summary: Enables phosphatidylinositol-3,4-bisphosphate binding activity and phospholipid binding activity. Involved in determination of adult lifespan; lipid homeostasis; and lipid transport involved in lipid storage. Located in cell body membrane and endoplasmic reticulum. Is expressed in adult fat body; adult head; and embryonic/larval fat body. Orthologous to human SNX25 (sorting nexin 25). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (7912089..7918444)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (7806122..7812477)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory transport and maintains the ultrafiltration diaphragm in nephrocytes.
Title: Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory transport and maintains the ultrafiltration diaphragm in nephrocytes.
Snz associates with lipid droplet population and regulates lipid droplet homeostasis at ER-PM contact sites.
Title: Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-3,4-bisphosphate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylserine binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phospholipid binding	ISM Inferred from Sequence Model more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport involved in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain