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Ppm1h protein phosphatase 1H (PP2C domain containing) [ Mus musculus (house mouse) ]

Gene ID: 319468, updated on 11-Apr-2024

Summary

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Official Symbol
Ppm1hprovided by MGI
Official Full Name
protein phosphatase 1H (PP2C domain containing)provided by MGI
Primary source
MGI:MGI:2442087
See related
Ensembl:ENSMUSG00000034613 AllianceGenome:MGI:2442087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARHCL1; A430075L18Rik; C030002B11Rik
Summary
Predicted to enable identical protein binding activity and phosphoprotein phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in synapse. Is active in glutamatergic synapse. Is expressed in ganglia; liver lobe; spinal cord; and thymus primordium. Orthologous to human PPM1H (protein phosphatase, Mg2+/Mn2+ dependent 1H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 12.2), kidney adult (RPKM 8.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D2; 10 70.44 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (122512720..122781700)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (122677428..122945795)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36284 Neighboring gene STARR-seq mESC enhancer starr_28126 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:122088945-122089304 Neighboring gene predicted gene, 40793 Neighboring gene microRNA 6412 Neighboring gene STARR-seq mESC enhancer starr_28127 Neighboring gene microRNA 8104 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:122179315-122179468 Neighboring gene STARR-seq mESC enhancer starr_28129 Neighboring gene STARR-seq mESC enhancer starr_28131 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:122237487-122237748 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:122252171-122252412 Neighboring gene predicted gene, 36208 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:122283655-122283857 Neighboring gene predicted gene, 51817 Neighboring gene STARR-seq mESC enhancer starr_28140 Neighboring gene predicted gene, 51818 Neighboring gene STARR-positive B cell enhancer ABC_E8375 Neighboring gene STARR-positive B cell enhancer ABC_E5196 Neighboring gene STARR-positive B cell enhancer ABC_E9356 Neighboring gene STARR-positive B cell enhancer ABC_E10651 Neighboring gene microRNA let7i Neighboring gene MON2 homolog, regulator of endosome to Golgi trafficking

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain. Khan SS, et al. Elife, 2021 Oct 18. PMID 34658337, Free PMC Article
  2. Dual phosphorylation of protein phosphatase PPM1H promotes dephosphorylation of Smad1 in cellulo. Osawa J, et al. Biochem Biophys Res Commun, 2020 Sep 24. PMID 32600616
  3. N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. Chida T, et al. Biochem J, 2013 Feb 1. PMID 23088624
  4. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. Biesemann C, et al. EMBO J, 2014 Jan 13. PMID 24413018, Free PMC Article
  5. Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Coulpier F, et al. Glia, 2009 Oct. PMID 19243017

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual phosphorylation of protein phosphatase PPM1H promotes dephosphorylation of Smad1 in cellulo.
    Title: Dual phosphorylation of protein phosphatase PPM1H promotes dephosphorylation of Smad1 in cellulo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein phosphatase 1H
NP_001103688.1
NP_795893.2
XP_006513805.1
XP_030100976.1
XP_036011702.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110218.1 → NP_001103688.1  protein phosphatase 1H isoform 1

    See identical proteins and their annotated locations for NP_001103688.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC159503, AK043121, AK134804, AK220260, BP769253, CK622851
    Consensus CDS
    CCDS48705.1
    UniProtKB/Swiss-Prot
    Q3UD05, Q3UYC0, Q3V3H5, Q3V3Y7, Q571C9, Q7TMU7, Q8BYE6
    Related
    ENSMUSP00000066561.6, ENSMUST00000067918.12
    Conserved Domains (1) summary
    cd00143
    Location:142 → 506
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  2. NM_176919.4 → NP_795893.2  protein phosphatase 1H isoform 2

    See identical proteins and their annotated locations for NP_795893.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the 3' terminal exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK040194, AK040207, AK043121, AK220260
    Consensus CDS
    CCDS48706.1
    UniProtKB/Swiss-Prot
    Q3UYC0
    Related
    ENSMUSP00000124982.2, ENSMUST00000161487.8
    Conserved Domains (1) summary
    cd00143
    Location:142 → 462
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    122512720..122781700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245116.2 → XP_030100976.1  protein phosphatase 1H isoform X2

    Conserved Domains (1) summary
    cd00143
    Location:1 → 256
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  2. XM_036155809.1 → XP_036011702.1  protein phosphatase 1H isoform X2

    Conserved Domains (1) summary
    cd00143
    Location:1 → 256
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  3. XM_006513742.4 → XP_006513805.1  protein phosphatase 1H isoform X1

    Conserved Domains (1) summary
    cd00143
    Location:7 → 262
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RNA

  1. XR_004936202.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UYC0.1 GenPept UniProtKB/Swiss-Prot:Q3UYC0

Gene LinkOut

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