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Zfp672 zinc finger protein 672 [ Mus musculus (house mouse) ]

Gene ID: 319475, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp672provided by MGI
Official Full Name
zinc finger protein 672provided by MGI
Primary source
MGI:MGI:2442105
See related
Ensembl:ENSMUSG00000049755 AllianceGenome:MGI:2442105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf672; 4930488P06Rik; 4930511N19Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF672 (zinc finger protein 672). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 6.1), ovary adult (RPKM 5.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp672 in Genome Data Viewer
Location:
11 B1.3; 11 36.19 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58205940..58221197, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58315114..58330368, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39827 Neighboring gene nuclear encoded tRNA glutamic acid 10 (anticodon CTC) Neighboring gene STARR-positive B cell enhancer ABC_E2989 Neighboring gene nuclear encoded tRNA leucine 3 (anticodon CAA) Neighboring gene zinc finger protein 692 Neighboring gene STARR-positive B cell enhancer ABC_E3953 Neighboring gene SH3 binding domain protein 5 like Neighboring gene predicted gene, 33660

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 672

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256516.1 → NP_001243445.1  zinc finger protein 672

    See identical proteins and their annotated locations for NP_001243445.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. Variants 1 and 3-7 all encode the functional protein.
    Source sequence(s)
    AK085166, BF730817, CA321162, DV654279
    Consensus CDS
    CCDS24727.1
    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001256517.1 → NP_001243446.1  zinc finger protein 672

    See identical proteins and their annotated locations for NP_001243446.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. Variants 1 and 3-7 all encode the functional protein.
    Source sequence(s)
    AK085166, AL845463, BF730817, DV654279
    Consensus CDS
    CCDS24727.1
    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Related
    ENSMUSP00000060088.6, ENSMUST00000057836.12
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001256518.1 → NP_001243447.1  zinc finger protein 672

    See identical proteins and their annotated locations for NP_001243447.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript. Variants 1 and 3-7 all encode the functional protein.
    Source sequence(s)
    AK029711, AK085166, AL845463, BB615378, BF730817
    Consensus CDS
    CCDS24727.1
    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Related
    ENSMUSP00000104457.2, ENSMUST00000108829.8
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001256519.1 → NP_001243448.1  zinc finger protein 672

    See identical proteins and their annotated locations for NP_001243448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 5. Variants 1 and 3-7 all encode the functional protein.
    Source sequence(s)
    AK085166, AL845463, BF730817, CV783882, DV654279
    Consensus CDS
    CCDS24727.1
    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001256520.1 → NP_001243449.1  zinc finger protein 672

    See identical proteins and their annotated locations for NP_001243449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 1 and 3-7 all encode the functional protein.
    Source sequence(s)
    AK085166, AL845463, BF730817, CV562361
    Consensus CDS
    CCDS24727.1
    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  6. NM_178761.5 → NP_848876.2  zinc finger protein 672

    See identical proteins and their annotated locations for NP_848876.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1 and 3-7 all encode the functional protein.
    Source sequence(s)
    AK035113, AK085166, BF730817, DV654279
    Consensus CDS
    CCDS24727.1
    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Related
    ENSMUSP00000070567.6, ENSMUST00000064786.12
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_028331.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' and 3' end exon structure compared to variant 5. This variant is represented as non-coding because it lacks the entire coding region, as found in all the coding variants.
    Source sequence(s)
    AK019676, BY715308, DV654279
    Related
    ENSMUST00000130217.2

  2. NR_046280.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains alternate exon structure in the 5' and 3' regions, compared to variant 5. This variant is represented as non-coding because it lacks the entire coding region, as found in all the coding variants.
    Source sequence(s)
    BG091612, BY715308, DV654279
    Related
    ENSMUST00000135097.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58205940..58221197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156758.1 → XP_036012651.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  2. XM_030246072.1 → XP_030101932.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  3. XM_030246074.2 → XP_030101934.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  4. XM_036156756.1 → XP_036012649.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  5. XM_030246076.2 → XP_030101936.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  6. XM_030246071.2 → XP_030101931.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  7. XM_017314590.2 → XP_017170079.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  8. XM_030246078.2 → XP_030101938.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  9. XM_030246073.2 → XP_030101933.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  10. XM_030246077.2 → XP_030101937.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  11. XM_030246075.2 → XP_030101935.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  12. XM_030246070.2 → XP_030101930.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  13. XM_017314591.2 → XP_017170080.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  14. XM_006533520.4 → XP_006533583.1  zinc finger protein 672 isoform X1

    See identical proteins and their annotated locations for XP_006533583.1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  15. XM_030246069.2 → XP_030101929.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  16. XM_036156757.1 → XP_036012650.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  17. XM_011249069.3 → XP_011247371.1  zinc finger protein 672 isoform X1

    See identical proteins and their annotated locations for XP_011247371.1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

  18. XM_036156755.1 → XP_036012648.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q8BIR7, Q99LH4
    Conserved Domains (4) summary
    COG5048
    Location:121 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 380
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183269.1: Suppressed sequence

    Description
    NM_183269.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LH4.1 GenPept UniProtKB/Swiss-Prot:Q99LH4

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