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Trmt9b tRNA methyltransferase 9B [ Mus musculus (house mouse) ]

Gene ID: 319582, updated on 5-Mar-2024

Summary

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Official Symbol
Trmt9bprovided by MGI
Official Full Name
tRNA methyltransferase 9Bprovided by MGI
Primary source
MGI:MGI:2442328
See related
Ensembl:ENSMUSG00000039620 AllianceGenome:MGI:2442328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRM9L; Kiaa1456; 6430573F11Rik
Summary
Predicted to enable tRNA binding activity and tRNA methyltransferase activity. Predicted to be involved in tRNA wobble uridine modification. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be active in cytoplasm and nucleus. Is expressed in nervous system and retina. Orthologous to human TRMT9B (tRNA methyltransferase 9B (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 4.9), frontal lobe adult (RPKM 2.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Trmt9b in Genome Data Viewer
Location:
8 A4; 8 23.05 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (36924643..36981738)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (36457485..36514584)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26150 Neighboring gene ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_21216 Neighboring gene STARR-seq mESC enhancer starr_21218 Neighboring gene STARR-seq mESC enhancer starr_21219 Neighboring gene STARR-seq mESC enhancer starr_21224 Neighboring gene predicted gene, 57789 Neighboring gene deleted in liver cancer 1 Neighboring gene STARR-seq mESC enhancer starr_21231 Neighboring gene predicted gene, 53416

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable tRNA methyltransferase 9B
Names
probable tRNA methyltransferase 9-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384099.1 → NP_001371028.1  probable tRNA methyltransferase 9B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC168051
    UniProtKB/Swiss-Prot
    Q5DTX8, Q80WQ4, Q8CA94, Q8CAM3
    Conserved Domains (1) summary
    pfam13649
    Location:48 → 135
    Methyltransf_25; Methyltransferase domain

  2. NM_001384103.1 → NP_001371032.1  probable tRNA methyltransferase 9B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC168051
    UniProtKB/Swiss-Prot
    Q5DTX8, Q80WQ4, Q8CA94, Q8CAM3
    Related
    ENSMUSP00000119912.2, ENSMUST00000147525.9
    Conserved Domains (1) summary
    pfam13649
    Location:48 → 135
    Methyltransf_25; Methyltransferase domain

  3. NM_176952.5 → NP_795926.2  probable tRNA methyltransferase 9B isoform 1

    See identical proteins and their annotated locations for NP_795926.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC168051
    Consensus CDS
    CCDS22248.1
    UniProtKB/Swiss-Prot
    Q5DTX8, Q80WQ4, Q8CA94, Q8CAM3
    Related
    ENSMUSP00000127875.2, ENSMUST00000171777.2
    Conserved Domains (1) summary
    pfam13649
    Location:48 → 135
    Methyltransf_25; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    36924643..36981738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509136.5 → XP_006509199.1  probable tRNA methyltransferase 9B isoform X1

    See identical proteins and their annotated locations for XP_006509199.1

    UniProtKB/Swiss-Prot
    Q5DTX8, Q80WQ4, Q8CA94, Q8CAM3
    Conserved Domains (1) summary
    pfam13649
    Location:48 → 135
    Methyltransf_25; Methyltransferase domain

  2. XM_006509138.2 → XP_006509201.1  probable tRNA methyltransferase 9B isoform X4

  3. XM_036154094.1 → XP_036009987.1  probable tRNA methyltransferase 9B isoform X3

    Conserved Domains (1) summary
    pfam13649
    Location:19 → 44
    Methyltransf_25; Methyltransferase domain

  4. XM_036154093.1 → XP_036009986.1  probable tRNA methyltransferase 9B isoform X2

    Conserved Domains (1) summary
    pfam13649
    Location:52 → 77
    Methyltransf_25; Methyltransferase domain

  5. XM_006509137.3 → XP_006509200.1  probable tRNA methyltransferase 9B isoform X3

    Conserved Domains (1) summary
    pfam13649
    Location:19 → 44
    Methyltransf_25; Methyltransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80WQ4.1 GenPept UniProtKB/Swiss-Prot:Q80WQ4

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