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Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor [ Mus musculus (house mouse) ]

Gene ID: 319594, updated on 16-Oct-2021

Summary

Official Symbol
Hif1anprovided by MGI
Official Full Name
hypoxia-inducible factor 1, alpha subunit inhibitorprovided by MGI
Primary source
MGI:MGI:2442345
See related
Ensembl:ENSMUSG00000036450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FIH; FIH1; 2310046M24Rik; A830014H24Rik
Expression
Ubiquitous expression in heart adult (RPKM 12.4), CNS E11.5 (RPKM 11.6) and 28 other tissues See more
Orthologs
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Genomic context

See Hif1an in Genome Data Viewer
Location:
19; 19 C3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44551293..44564713)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44562854..44576274)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (44637344..44650764)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene Sec31 homolog B (S. cerevisiae) Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 Neighboring gene predicted gene, 35460 Neighboring gene predicted gene, 41854

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 
enables ankyrin repeat binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ankyrin repeat binding ISO
Inferred from Sequence Orthology
more info
 
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
enables hypoxia-inducible factor-asparagine oxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-asparagine 3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidyl-asparagine 3-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidyl-histidine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidyl-histidine dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hypoxia-inducible factor 1-alpha inhibitor
Names
hypoxia-inducible factor asparagine hydroxylase
NP_795932.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176958.3NP_795932.2  hypoxia-inducible factor 1-alpha inhibitor

    See identical proteins and their annotated locations for NP_795932.2

    Status: VALIDATED

    Source sequence(s)
    AC151478, BY122345, BY713373, CN535711
    Consensus CDS
    CCDS29852.1
    UniProtKB/Swiss-Prot
    Q8BLR9
    Related
    ENSMUSP00000035326.5, ENSMUST00000040455.5
    Conserved Domains (1) summary
    pfam13621
    Location:53297
    Cupin_8; Cupin-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    44551293..44564713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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