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Usp37 ubiquitin specific peptidase 37 [ Mus musculus (house mouse) ]

Gene ID: 319651, updated on 21-Apr-2024

Summary

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Official Symbol
Usp37provided by MGI
Official Full Name
ubiquitin specific peptidase 37provided by MGI
Primary source
MGI:MGI:2442483
See related
Ensembl:ENSMUSG00000033364 AllianceGenome:MGI:2442483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932415L06Rik; C330008N13Rik
Summary
Predicted to enable cysteine-type endopeptidase activity; protein kinase binding activity; and thiol-dependent deubiquitinase. Predicted to be involved in G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of DNA replication. Predicted to act upstream of or within cell division. Predicted to be active in cytosol and nucleus. Orthologous to human USP37 (ubiquitin specific peptidase 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 7.5), small intestine adult (RPKM 7.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C3- C4; 1 38.54 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74474669..74583447, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74435510..74544286, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:74433475-74433675 Neighboring gene STARR-positive B cell enhancer ABC_E2549 Neighboring gene solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Neighboring gene STARR-seq mESC enhancer starr_01337 Neighboring gene predicted gene, 53562 Neighboring gene CTD small phosphatase 1 Neighboring gene microRNA 26b Neighboring gene villin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:74552349-74552650 Neighboring gene CCR4-NOT transcription complex, subunit 9 Neighboring gene phospholipase C, delta 4 Neighboring gene STARR-seq mESC enhancer starr_01339 Neighboring gene zinc finger protein 142 Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37. Qin S, et al. Nucleic Acids Res, 2022 Sep 9. PMID 36029179, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37.
    Title: Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 37
Names
deubiquitinating enzyme 37
ubiquitin specific protease 37
ubiquitin thioesterase 37
ubiquitin thiolesterase 37
ubiquitin-specific-processing protease 37
NP_001297591.1
NP_795946.2
XP_006496117.1
XP_006496120.1
XP_036021582.1
XP_036021584.1
XP_036021585.1
XP_036021586.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310662.1 → NP_001297591.1  ubiquitin carboxyl-terminal hydrolase 37 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC098570, AK030013, AK035640, BB624535
    Consensus CDS
    CCDS78616.1
    UniProtKB/Swiss-Prot
    B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
    Related
    ENSMUSP00000035445.6, ENSMUST00000044260.11
    Conserved Domains (4) summary
    cd02257
    Location:342 → 601
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cl02553
    Location:342 → 449
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 600
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  2. NM_176972.4 → NP_795946.2  ubiquitin carboxyl-terminal hydrolase 37 isoform 1

    See identical proteins and their annotated locations for NP_795946.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC098570, AK030013, BC139091
    Consensus CDS
    CCDS15050.1
    UniProtKB/Swiss-Prot
    B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
    UniProtKB/TrEMBL
    A0A0R4J2D0
    Related
    ENSMUSP00000140670.2, ENSMUST00000189257.7
    Conserved Domains (3) summary
    cd02257
    Location:886 → 949
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 105
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74474669..74583447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165692.1 → XP_036021585.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    UniProtKB/Swiss-Prot
    B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
    UniProtKB/TrEMBL
    A0A0R4J2D0
    Conserved Domains (3) summary
    cd02257
    Location:886 → 949
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 105
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  2. XM_006496057.5 → XP_006496120.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

    UniProtKB/Swiss-Prot
    B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
    Conserved Domains (3) summary
    COG5207
    Location:342 → 936
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    pfam00443
    Location:342 → 601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 105
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  3. XM_006496054.4 → XP_006496117.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_006496117.1

    UniProtKB/Swiss-Prot
    B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
    UniProtKB/TrEMBL
    A0A0R4J2D0
    Conserved Domains (3) summary
    cd02257
    Location:886 → 949
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 105
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  4. XM_036165691.1 → XP_036021584.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    UniProtKB/Swiss-Prot
    B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
    UniProtKB/TrEMBL
    A0A0R4J2D0
    Conserved Domains (3) summary
    cd02257
    Location:886 → 949
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 105
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  5. XM_036165689.1 → XP_036021582.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    UniProtKB/Swiss-Prot
    B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
    UniProtKB/TrEMBL
    A0A0R4J2D0
    Conserved Domains (3) summary
    cd02257
    Location:886 → 949
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342 → 601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 105
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  6. XM_036165693.1 → XP_036021586.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X3

    UniProtKB/Swiss-Prot
    B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
    Conserved Domains (2) summary
    pfam00443
    Location:342 → 601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 105
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

RNA

  1. XR_373256.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0R0.1 GenPept UniProtKB/Swiss-Prot:Q8C0R0

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