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Fbxo48 F-box protein 48 [ Mus musculus (house mouse) ]

Gene ID: 319701, updated on 5-Mar-2024

Summary

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Official Symbol
Fbxo48provided by MGI
Official Full Name
F-box protein 48provided by MGI
Primary source
MGI:MGI:2442569
See related
Ensembl:ENSMUSG00000044966 AllianceGenome:MGI:2442569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630050E13Rik
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in axial skeleton; liver; midbrain ventricular layer; and telencephalon ventricular layer. Orthologous to human FBXO48 (F-box protein 48). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 2.1), liver E14.5 (RPKM 1.8) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A2; 11 9.41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16901225..16908516)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16951224..16954777)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor receptor Neighboring gene predicted gene, 39584 Neighboring gene STARR-seq mESC enhancer starr_28696 Neighboring gene epidermal growth factor receptor, opposite strand Neighboring gene STARR-seq mESC enhancer starr_28697 Neighboring gene STARR-seq mESC enhancer starr_28698 Neighboring gene STARR-seq mESC enhancer starr_28699 Neighboring gene STARR-seq mESC enhancer starr_28700 Neighboring gene Egfr long non-coding downstream RNA Neighboring gene STARR-positive B cell enhancer ABC_E8386 Neighboring gene pleckstrin Neighboring gene STARR-positive B cell enhancer ABC_E1819 Neighboring gene signal peptide, CUB domain, EGF-like 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
F-box only protein 48
Names
novel F-box domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359162.1 → NP_001346091.1  F-box only protein 48

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK037835, AK041978
    Consensus CDS
    CCDS24445.1
    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Related
    ENSMUSP00000105263.2, ENSMUST00000109635.2
    Conserved Domains (1) summary
    pfam12937
    Location:38 → 77
    F-box-like

  2. NM_176982.2 → NP_795956.1  F-box only protein 48

    See identical proteins and their annotated locations for NP_795956.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK037835
    Consensus CDS
    CCDS24445.1
    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Related
    ENSMUSP00000057901.2, ENSMUST00000061327.2
    Conserved Domains (1) summary
    pfam12937
    Location:38 → 77
    F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    16901225..16908516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514732.5 → XP_006514795.1  F-box only protein 48 isoform X1

    See identical proteins and their annotated locations for XP_006514795.1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:38 → 77
    F-box-like

  2. XM_006514731.5 → XP_006514794.1  F-box only protein 48 isoform X1

    See identical proteins and their annotated locations for XP_006514794.1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:38 → 77
    F-box-like

  3. XM_017314603.3 → XP_017170092.1  F-box only protein 48 isoform X1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:38 → 77
    F-box-like

  4. XM_006514728.5 → XP_006514791.1  F-box only protein 48 isoform X1

    See identical proteins and their annotated locations for XP_006514791.1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:38 → 77
    F-box-like

  5. XM_017314602.3 → XP_017170091.1  F-box only protein 48 isoform X1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:38 → 77
    F-box-like

  6. XM_017314604.3 → XP_017170093.1  F-box only protein 48 isoform X1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:38 → 77
    F-box-like

  7. XM_011243726.4 → XP_011242028.1  F-box only protein 48 isoform X1

    See identical proteins and their annotated locations for XP_011242028.1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:38 → 77
    F-box-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CAT8.1 GenPept UniProtKB/Swiss-Prot:Q8CAT8

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