U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ablim3 actin binding LIM protein family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 319713, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Ablim3provided by MGI
Official Full Name
actin binding LIM protein family, member 3provided by MGI
Primary source
MGI:MGI:2442582
See related
Ensembl:ENSMUSG00000032735 AllianceGenome:MGI:2442582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D930036B08Rik
Summary
Predicted to enable actin filament binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in glutamatergic synapse. Is active in synapse. Is expressed in several structures, including central nervous system; heart; neural retina; skeletal muscle tissue; and trigeminal nerve. Orthologous to human ABLIM3 (actin binding LIM protein family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 16.1), CNS E18 (RPKM 14.9) and 17 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
18 E1; 18 34.77 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61932463..62044956, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61799392..61911885, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1500015A07 gene Neighboring gene GrpE-like 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E7594 Neighboring gene actin filament associated protein 1-like 1 Neighboring gene predicted gene, 41748 Neighboring gene STARR-seq mESC enhancer starr_44765 Neighboring gene predicted gene, 35919 Neighboring gene STARR-positive B cell enhancer ABC_E10996 Neighboring gene predicted gene, 35720 Neighboring gene SH3 domain and tetratricopeptide repeats 2 Neighboring gene STARR-seq mESC enhancer starr_44766

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. abLIM3 is a novel component of adherens junctions with actin-binding activity. Matsuda M, et al. Eur J Cell Biol, 2010 Nov. PMID 20709423
  2. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. Barrientos T, et al. J Biol Chem, 2007 Mar 16. PMID 17194709
  3. SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis. Liu CF, et al. Development, 2018 Jul 18. PMID 30021842, Free PMC Article
  4. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Cao J, et al. Nat Cell Biol, 2012 Jun 10. PMID 22684256
  5. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABLIM-2 and -3 associate with STARS and directly bind F-actin
    Title: Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA0843, MGC69876

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
actin-binding LIM protein 3
Names
abLIM-3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164491.1 → NP_001157963.1  actin-binding LIM protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001157963.1

    Status: VALIDATED

    Source sequence(s)
    AC091677, BC060275, CF171696
    Consensus CDS
    CCDS37839.1
    UniProtKB/Swiss-Prot
    Q52KR1, Q69ZX8, Q6PAI7
    Related
    ENSMUSP00000125836.2, ENSMUST00000166783.3
    Conserved Domains (6) summary
    smart00153
    Location:647 → 682
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 645
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  2. NM_001360868.1 → NP_001347797.1  actin-binding LIM protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091677, AC125157
    Conserved Domains (6) summary
    smart00153
    Location:614 → 649
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 612
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  3. NM_198649.3 → NP_941051.2  actin-binding LIM protein 3 isoform 1

    See identical proteins and their annotated locations for NP_941051.2

    Status: VALIDATED

    Source sequence(s)
    AC091677, BC094229
    Consensus CDS
    CCDS37839.1
    UniProtKB/Swiss-Prot
    Q52KR1, Q69ZX8, Q6PAI7
    Related
    ENSMUSP00000041243.9, ENSMUST00000049378.15
    Conserved Domains (6) summary
    smart00153
    Location:647 → 682
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 645
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61932463..62044956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250507.2 → XP_030106367.1  actin-binding LIM protein 3 isoform X7

    Conserved Domains (6) summary
    smart00153
    Location:536 → 571
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 534
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  2. XM_030250506.1 → XP_030106366.1  actin-binding LIM protein 3 isoform X4

    Conserved Domains (6) summary
    smart00153
    Location:598 → 633
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 596
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  3. XM_036161169.1 → XP_036017062.1  actin-binding LIM protein 3 isoform X2

    Conserved Domains (6) summary
    smart00153
    Location:631 → 666
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 630
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  4. XM_006526006.5 → XP_006526069.1  actin-binding LIM protein 3 isoform X2

    Conserved Domains (6) summary
    smart00153
    Location:631 → 666
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 630
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  5. XM_006526005.5 → XP_006526068.1  actin-binding LIM protein 3 isoform X1

    Conserved Domains (6) summary
    smart00153
    Location:637 → 672
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 635
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  6. XM_006526010.5 → XP_006526073.1  actin-binding LIM protein 3 isoform X6

    Conserved Domains (6) summary
    smart00153
    Location:552 → 587
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 550
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  7. XM_006526009.5 → XP_006526072.1  actin-binding LIM protein 3 isoform X5

    Conserved Domains (6) summary
    smart00153
    Location:585 → 620
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 583
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  8. XM_006526008.5 → XP_006526071.1  actin-binding LIM protein 3 isoform X4

    Conserved Domains (6) summary
    smart00153
    Location:598 → 633
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 596
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  9. XM_006526007.5 → XP_006526070.1  actin-binding LIM protein 3 isoform X3

    Conserved Domains (6) summary
    smart00153
    Location:614 → 649
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 612
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  10. XM_030250508.1 → XP_030106368.1  actin-binding LIM protein 3 isoform X8

    Conserved Domains (4) summary
    smart00153
    Location:511 → 546
    VHP; Villin headpiece domain
    cd09329
    Location:15 → 66
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:74 → 129
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:137 → 509
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  11. XM_006526012.2 → XP_006526075.1  actin-binding LIM protein 3 isoform X9

    Conserved Domains (3) summary
    smart00153
    Location:408 → 443
    VHP; Villin headpiece domain
    cl02475
    Location:12 → 26
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:34 → 406
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZX8.2 GenPept UniProtKB/Swiss-Prot:Q69ZX8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous