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Zfp865 zinc finger protein 865 [ Mus musculus (house mouse) ]

Gene ID: 319748, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp865provided by MGI
Official Full Name
zinc finger protein 865provided by MGI
Primary source
MGI:MGI:2442656
See related
Ensembl:ENSMUSG00000074405 AllianceGenome:MGI:2442656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf865; 6430526N21Rik
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF865 (zinc finger protein 865). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 26.9), adrenal adult (RPKM 25.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp865 in Genome Data Viewer
Location:
7 A1; 7 2.9 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (5023375..5036225)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (5020376..5033226)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Flt3 interacting zinc finger protein 1 Neighboring gene STARR-seq mESC enhancer starr_17950 Neighboring gene zinc finger protein 524 Neighboring gene STARR-positive B cell enhancer ABC_E4889 Neighboring gene STARR-positive B cell enhancer ABC_E3696 Neighboring gene zinc finger protein 784 Neighboring gene zinc finger protein 580 Neighboring gene STARR-positive B cell enhancer ABC_E4890 Neighboring gene predicted gene 15510

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 865

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033383.2 → NP_001028555.1  zinc finger protein 865 isoform 1

    See identical proteins and their annotated locations for NP_001028555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK154737
    Consensus CDS
    CCDS20753.1
    UniProtKB/Swiss-Prot
    D3Z3M5, Q3U3I9
    Related
    ENSMUSP00000075601.5, ENSMUST00000076251.7
    Conserved Domains (6) summary
    PHA03247
    Location:272 → 343
    PHA03247; large tegument protein UL36; Provisional
    PHA03378
    Location:163 → 349
    PHA03378; EBNA-3B; Provisional
    COG5048
    Location:349 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:548 → 568
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:561 → 584
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001290426.1 → NP_001277355.1  zinc finger protein 865 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC157563, AK051004, BY205386
    Consensus CDS
    CCDS71884.1
    UniProtKB/TrEMBL
    H9KUY5
    Related
    ENSMUSP00000082550.4, ENSMUST00000085427.6
    Conserved Domains (6) summary
    COG5048
    Location:349 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:548 → 568
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:666 → 686
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220 → 242
    zf-C2H2; Zinc finger, C2H2 type
    pfam12446
    Location:272 → 348
    DUF3682; Protein of unknown function (DUF3682)
    pfam13465
    Location:561 → 583
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    5023375..5036225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540059.3 → XP_006540122.1  zinc finger protein 865 isoform X2

    See identical proteins and their annotated locations for XP_006540122.1

    UniProtKB/Swiss-Prot
    D3Z3M5, Q3U3I9
    Conserved Domains (6) summary
    PHA03247
    Location:272 → 343
    PHA03247; large tegument protein UL36; Provisional
    PHA03378
    Location:163 → 349
    PHA03378; EBNA-3B; Provisional
    COG5048
    Location:349 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:548 → 568
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:561 → 584
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017322300.3 → XP_017177789.1  zinc finger protein 865 isoform X3

    Conserved Domains (7) summary
    PHA03247
    Location:334 → 405
    PHA03247; large tegument protein UL36; Provisional
    PHA03378
    Location:225 → 411
    PHA03378; EBNA-3B; Provisional
    COG5048
    Location:411 → 483
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:632 → 683
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:610 → 630
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:728 → 748
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:623 → 646
    zf-H2C2_2; Zinc-finger double domain

  3. XM_017322299.1 → XP_017177788.1  zinc finger protein 865 isoform X1

    Conserved Domains (6) summary
    PHA03247
    Location:334 → 405
    PHA03247; large tegument protein UL36; Provisional
    PHA03378
    Location:225 → 411
    PHA03378; EBNA-3B; Provisional
    COG5048
    Location:411 → 483
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:610 → 630
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:623 → 646
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006540060.1 → XP_006540123.1  zinc finger protein 865 isoform X2

    See identical proteins and their annotated locations for XP_006540123.1

    UniProtKB/Swiss-Prot
    D3Z3M5, Q3U3I9
    Conserved Domains (6) summary
    PHA03247
    Location:272 → 343
    PHA03247; large tegument protein UL36; Provisional
    PHA03378
    Location:163 → 349
    PHA03378; EBNA-3B; Provisional
    COG5048
    Location:349 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:548 → 568
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:561 → 584
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U3I9.1 GenPept UniProtKB/Swiss-Prot:Q3U3I9

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