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Cobll1 Cobl-like 1 [ Mus musculus (house mouse) ]

Gene ID: 319876, updated on 5-Mar-2024

Summary

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Official Symbol
Cobll1provided by MGI
Official Full Name
Cobl-like 1provided by MGI
Primary source
MGI:MGI:2442894
See related
Ensembl:ENSMUSG00000034903 AllianceGenome:MGI:2442894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Coblr1; 1810047P18Rik; D430044D16Rik
Summary
Predicted to enable actin monomer binding activity. Is expressed in several structures, including 1st branchial arch; alimentary system; extraembryonic component; forelimb bud; and nose. Orthologous to human COBLL1 (cordon-bleu WH2 repeat protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 24.9), kidney adult (RPKM 14.3) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Cobll1 in Genome Data Viewer
Location:
2 C1.3; 2 38.35 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (64918683..65069742, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (65088339..65239398, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13578 Neighboring gene growth factor receptor bound protein 14 Neighboring gene STARR-seq mESC enhancer starr_04666 Neighboring gene STARR-seq mESC enhancer starr_04667 Neighboring gene STARR-positive B cell enhancer mm9_chr2:64959532-64959832 Neighboring gene predicted gene, 57691 Neighboring gene STARR-seq mESC enhancer starr_04668 Neighboring gene STARR-positive B cell enhancer ABC_E4459 Neighboring gene STARR-seq mESC enhancer starr_04669 Neighboring gene STARR-seq mESC enhancer starr_04670 Neighboring gene predicted gene 13594 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 13593

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cordon-bleu is a conserved gene involved in neural tube formation. Carroll EA, et al. Dev Biol, 2003 Oct 1. PMID 14512015
  2. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  3. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cordon-bleu protein-like 1
Names
cobl-related 1
cobl-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363076.1 → NP_001350005.1  cordon-bleu protein-like 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL929129, AL929132, AL935171, BX321909
    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    pfam09469
    Location:188 → 266
    Cobl; Cordon-bleu ubiquitin-like domain
    cl26464
    Location:905 → 1176
    Atrophin-1; Atrophin-1 family

  2. NM_001363077.1 → NP_001350006.1  cordon-bleu protein-like 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL929129, AL929132, AL935171
    Consensus CDS
    CCDS89492.1
    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    UniProtKB/TrEMBL
    B1AZ14, D3Z6S2
    Related
    ENSMUSP00000108050.2, ENSMUST00000112431.8
    Conserved Domains (2) summary
    pfam09469
    Location:156 → 234
    Cobl; Cordon-bleu ubiquitin-like domain
    cl26464
    Location:873 → 1144
    Atrophin-1; Atrophin-1 family

  3. NM_027225.2 → NP_081501.1  cordon-bleu protein-like 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL929129, AL929132, AL935171
    Consensus CDS
    CCDS50595.1
    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Related
    ENSMUSP00000088412.4, ENSMUST00000090896.10
    Conserved Domains (2) summary
    pfam09469
    Location:156 → 234
    Cobl; Cordon-bleu ubiquitin-like domain
    cl00155
    Location:72 → 141
    UBQ; Ubiquitin-like proteins

  4. NM_177025.6 → NP_795999.2  cordon-bleu protein-like 1 isoform 1

    See identical proteins and their annotated locations for NP_795999.2

    Status: VALIDATED

    Source sequence(s)
    AL929129, AL929132, AL935171
    Consensus CDS
    CCDS16072.1
    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    UniProtKB/TrEMBL
    B1AZ15
    Related
    ENSMUSP00000099787.2, ENSMUST00000102726.8
    Conserved Domains (3) summary
    pfam09528
    Location:286 → 840
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    pfam09469
    Location:156 → 234
    Cobl; Cordon-bleu ubiquitin-like domain
    cl00155
    Location:72 → 141
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    64918683..65069742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499717.3 → XP_006499780.1  cordon-bleu protein-like 1 isoform X9

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:885 → 1156
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:155 → 231
    Cobl; Cordon-bleu ubiquitin-like domain

  2. XM_006499716.5 → XP_006499779.1  cordon-bleu protein-like 1 isoform X8

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:886 → 1157
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:156 → 232
    Cobl; Cordon-bleu ubiquitin-like domain

  3. XM_011239598.4 → XP_011237900.1  cordon-bleu protein-like 1 isoform X4

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:906 → 1177
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:176 → 252
    Cobl; Cordon-bleu ubiquitin-like domain

  4. XM_006499711.5 → XP_006499774.1  cordon-bleu protein-like 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:905 → 1176
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:175 → 251
    Cobl; Cordon-bleu ubiquitin-like domain

  5. XM_006499715.5 → XP_006499778.1  cordon-bleu protein-like 1 isoform X7

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:892 → 1163
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:176 → 254
    Cobl; Cordon-bleu ubiquitin-like domain

  6. XM_006499712.5 → XP_006499775.1  cordon-bleu protein-like 1 isoform X3

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:905 → 1176
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:176 → 252
    Cobl; Cordon-bleu ubiquitin-like domain

  7. XM_006499710.5 → XP_006499773.1  cordon-bleu protein-like 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:906 → 1177
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:176 → 252
    Cobl; Cordon-bleu ubiquitin-like domain

  8. XM_030251742.2 → XP_030107602.1  cordon-bleu protein-like 1 isoform X17

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:853 → 1124
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:175 → 253
    Cobl; Cordon-bleu ubiquitin-like domain

  9. XM_006499722.5 → XP_006499785.1  cordon-bleu protein-like 1 isoform X15

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:854 → 1125
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:175 → 253
    Cobl; Cordon-bleu ubiquitin-like domain

  10. XM_006499714.5 → XP_006499777.1  cordon-bleu protein-like 1 isoform X6

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:892 → 1163
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:175 → 253
    Cobl; Cordon-bleu ubiquitin-like domain

  11. XM_030251741.2 → XP_030107601.1  cordon-bleu protein-like 1 isoform X16

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:854 → 1125
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:176 → 254
    Cobl; Cordon-bleu ubiquitin-like domain

  12. XM_006499721.5 → XP_006499784.1  cordon-bleu protein-like 1 isoform X14

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:855 → 1126
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:176 → 254
    Cobl; Cordon-bleu ubiquitin-like domain

  13. XM_006499713.5 → XP_006499776.1  cordon-bleu protein-like 1 isoform X5

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:893 → 1164
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:176 → 254
    Cobl; Cordon-bleu ubiquitin-like domain

  14. XM_006499718.5 → XP_006499781.1  cordon-bleu protein-like 1 isoform X11

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:868 → 1139
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:176 → 252
    Cobl; Cordon-bleu ubiquitin-like domain

  15. XM_030251750.1 → XP_030107610.1  cordon-bleu protein-like 1 isoform X21

    Conserved Domains (1) summary
    PHA03247
    Location:646 → 917
    PHA03247; large tegument protein UL36; Provisional

  16. XM_030251749.1 → XP_030107609.1  cordon-bleu protein-like 1 isoform X21

    Conserved Domains (1) summary
    PHA03247
    Location:646 → 917
    PHA03247; large tegument protein UL36; Provisional

  17. XM_036162291.1 → XP_036018184.1  cordon-bleu protein-like 1 isoform X10

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (5) summary
    PHA03247
    Location:873 → 1144
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:156 → 234
    Cobl; Cordon-bleu ubiquitin-like domain
    cd21762
    Location:1211 → 1214
    WH2; actin-binding sequence [structural motif]
    cl28922
    Location:72 → 136
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    cl41728
    Location:1190 → 1214
    WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

  18. XM_006499723.4 → XP_006499786.1  cordon-bleu protein-like 1 isoform X20

    See identical proteins and their annotated locations for XP_006499786.1

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:822 → 1093
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:92 → 168
    Cobl; Cordon-bleu ubiquitin-like domain

  19. XM_030251745.1 → XP_030107605.1  cordon-bleu protein-like 1 isoform X19

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:849 → 1120
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:132 → 210
    Cobl; Cordon-bleu ubiquitin-like domain

  20. XM_030251744.1 → XP_030107604.1  cordon-bleu protein-like 1 isoform X18

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:850 → 1121
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:133 → 211
    Cobl; Cordon-bleu ubiquitin-like domain

  21. XM_006499720.2 → XP_006499783.1  cordon-bleu protein-like 1 isoform X13

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:862 → 1133
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:132 → 208
    Cobl; Cordon-bleu ubiquitin-like domain

  22. XM_006499719.2 → XP_006499782.1  cordon-bleu protein-like 1 isoform X12

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:863 → 1134
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:133 → 209
    Cobl; Cordon-bleu ubiquitin-like domain

  23. XM_006499724.3 → XP_006499787.1  cordon-bleu protein-like 1 isoform X20

    See identical proteins and their annotated locations for XP_006499787.1

    UniProtKB/Swiss-Prot
    Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
    Conserved Domains (2) summary
    PHA03247
    Location:822 → 1093
    PHA03247; large tegument protein UL36; Provisional
    pfam09469
    Location:92 → 168
    Cobl; Cordon-bleu ubiquitin-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UMF0.2 GenPept UniProtKB/Swiss-Prot:Q3UMF0

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