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Dock6 dedicator of cytokinesis 6 [ Mus musculus (house mouse) ]

Gene ID: 319899, updated on 16-Apr-2024

Summary

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Official Symbol
Dock6provided by MGI
Official Full Name
dedicator of cytokinesis 6provided by MGI
Primary source
MGI:MGI:1914789
See related
Ensembl:ENSMUSG00000032198 AllianceGenome:MGI:1914789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1395; 2410095B20Rik; 4931431C02Rik; C330023D02Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to be located in cytosol. Is expressed in several structures, including brain; forelimb bud; head mesenchyme derived from neural crest; limb; and spleen. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DOCK6 (dedicator of cytokinesis 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 44.6), ovary adult (RPKM 27.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A3; 9 7.89 cM
Exon count:
50
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21711476..21764006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21800180..21852718, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1379 Neighboring gene STARR-seq mESC enhancer starr_23515 Neighboring gene SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene predicted gene, 39305 Neighboring gene microRNA 7083 Neighboring gene STARR-seq mESC enhancer starr_23526 Neighboring gene angiopoietin-like 8 Neighboring gene STARR-seq mESC enhancer starr_23527 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene transmembrane protein 205 Neighboring gene coiled-coil domain containing 159

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome. Shaheen R, et al. Am J Hum Genet, 2011 Aug 12. PMID 21820096, Free PMC Article
  2. Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth. Miyamoto Y, et al. Exp Cell Res, 2007 Feb 15. PMID 17196961
  3. Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons. Miyamoto Y, et al. Sci Signal, 2013 Mar 5. PMID 23462102
  4. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. phosphorylation status of Dock6 at Ser(1194) determines whether it promotes axon extension or branching in sensory neurons, revealing interplay between kinase and phosphatase action on a Rho-GEF during axon growth
    Title: Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons.
  2. Dock6 is the GEF specific for both Rac1 and Cdc42 and may be one of physiological regulators of neurite outgrowth.
    Title: Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dedicator of cytokinesis protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413912.1 → NP_001400841.1  dedicator of cytokinesis protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161371, AC166992
    UniProtKB/Swiss-Prot
    E9QKQ0, Q3UM59, Q6PFY0, Q8BJS1, Q8VDR9, Q9D461
    Related
    ENSMUSP00000034728.9, ENSMUST00000034728.9

  2. NM_177030.4 → NP_796004.2  dedicator of cytokinesis protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161371, AC166992
    Consensus CDS
    CCDS40555.1
    UniProtKB/TrEMBL
    A0A1L1SQR4, Q6ZPS1
    Related
    ENSMUSP00000149156.2, ENSMUST00000217336.2
    Conserved Domains (3) summary
    cd08696
    Location:545 → 722
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:65 → 155
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1656 → 2078
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21711476..21764006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155058.1 → XP_036010951.1  dedicator of cytokinesis protein 6 isoform X7

    UniProtKB/TrEMBL
    Q6ZPS1
    Conserved Domains (3) summary
    cd08696
    Location:545 → 722
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1590 → 2012
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  2. XM_017313426.3 → XP_017168915.1  dedicator of cytokinesis protein 6 isoform X1

    UniProtKB/TrEMBL
    Q6ZPS1
    Conserved Domains (3) summary
    cd08696
    Location:545 → 722
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1656 → 2078
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  3. XM_036155057.1 → XP_036010950.1  dedicator of cytokinesis protein 6 isoform X4

    UniProtKB/TrEMBL
    Q6ZPS1
    Conserved Domains (3) summary
    cd08696
    Location:545 → 722
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1590 → 2012
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  4. XM_011242553.3 → XP_011240855.1  dedicator of cytokinesis protein 6 isoform X3

    UniProtKB/TrEMBL
    Q6ZPS1
    Conserved Domains (3) summary
    cd08696
    Location:545 → 722
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1621 → 2043
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  5. XM_011242552.3 → XP_011240854.1  dedicator of cytokinesis protein 6 isoform X2

    UniProtKB/TrEMBL
    Q6ZPS1
    Conserved Domains (3) summary
    cd08696
    Location:545 → 722
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1625 → 2047
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  6. XM_006510422.3 → XP_006510485.1  dedicator of cytokinesis protein 6 isoform X5

    UniProtKB/TrEMBL
    Q6ZPS1
    Conserved Domains (3) summary
    cd08696
    Location:453 → 630
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:13 → 65
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1564 → 1986
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  7. XM_030244416.2 → XP_030100276.1  dedicator of cytokinesis protein 6 isoform X10

    Conserved Domains (1) summary
    cl06123
    Location:823 → 1245
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  8. XM_017313427.3 → XP_017168916.1  dedicator of cytokinesis protein 6 isoform X8

    UniProtKB/TrEMBL
    Q6ZPS1
    Conserved Domains (3) summary
    cd08696
    Location:545 → 722
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1617 → 1760
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  9. XM_011242555.4 → XP_011240857.1  dedicator of cytokinesis protein 6 isoform X9

    Conserved Domains (2) summary
    cd08696
    Location:545 → 722
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)

RNA

  1. XR_003947928.2 RNA Sequence

  2. XR_004935451.1 RNA Sequence

  3. XR_001778931.3 RNA Sequence

  4. XR_004935452.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDR9.4 GenPept UniProtKB/Swiss-Prot:Q8VDR9

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