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Apba1 amyloid beta (A4) precursor protein binding, family A, member 1 [ Mus musculus (house mouse) ]

Gene ID: 319924, updated on 16-Oct-2021

Summary

Official Symbol
Apba1provided by MGI
Official Full Name
amyloid beta (A4) precursor protein binding, family A, member 1provided by MGI
Primary source
MGI:MGI:1860297
See related
Ensembl:ENSMUSG00000024897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
X11; Mint; Mint1; Lin-10; Urop11; X11alpha; 6430513E09Rik
Expression
Broad expression in cortex adult (RPKM 21.6), cerebellum adult (RPKM 21.4) and 17 other tissues See more
Orthologs
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Genomic context

See Apba1 in Genome Data Viewer
Location:
19; 19 B
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (23736170..23926961)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (23758806..23949598)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (23833366..24024087)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene SAP domain containing ribonucleoprotein pseudogene Neighboring gene protein prenyltransferase alpha subunit repeat containing 1 Neighboring gene predicted gene, 34076 Neighboring gene family with sequence similarity 189, member A2 Neighboring gene predicted gene, 54056

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
amyloid-beta A4 precursor protein-binding family A member 1
Names
UROP11-110
adapter protein X11alpha
mint-1
neuron-specific X11 protein
neuronal Munc18-1-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177034.3NP_796008.2  amyloid-beta A4 precursor protein-binding family A member 1

    See identical proteins and their annotated locations for NP_796008.2

    Status: VALIDATED

    Source sequence(s)
    AI838602, AK032261, AK147583, CJ122547
    Consensus CDS
    CCDS50407.1
    UniProtKB/Swiss-Prot
    B2RUJ5
    Related
    ENSMUSP00000025830.8, ENSMUST00000025830.9
    Conserved Domains (3) summary
    cd00992
    Location:750823
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:457628
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:661744
    PDZ; PDZ domain (Also known as DHR or GLGF)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    23736170..23926961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527139.5XP_006527202.1  amyloid-beta A4 precursor protein-binding family A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006527202.1

    UniProtKB/Swiss-Prot
    B2RUJ5
    Conserved Domains (3) summary
    cd00992
    Location:750823
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:457628
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:661744
    PDZ; PDZ domain (Also known as DHR or GLGF)
  2. XM_006527140.5XP_006527203.1  amyloid-beta A4 precursor protein-binding family A member 1 isoform X2

    UniProtKB/Swiss-Prot
    B2RUJ5
    Conserved Domains (3) summary
    cd00992
    Location:739812
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:457617
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:650733
    PDZ; PDZ domain (Also known as DHR or GLGF)
  3. XM_030250969.2XP_030106829.1  amyloid-beta A4 precursor protein-binding family A member 1 isoform X2

    Conserved Domains (3) summary
    cd00992
    Location:739812
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:457617
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:650733
    PDZ; PDZ domain (Also known as DHR or GLGF)
  4. XM_030250968.2XP_030106828.1  amyloid-beta A4 precursor protein-binding family A member 1 isoform X1

    Conserved Domains (3) summary
    cd00992
    Location:750823
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:457628
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:661744
    PDZ; PDZ domain (Also known as DHR or GLGF)
  5. XM_030250967.2XP_030106827.1  amyloid-beta A4 precursor protein-binding family A member 1 isoform X1

    Conserved Domains (3) summary
    cd00992
    Location:750823
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:457628
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:661744
    PDZ; PDZ domain (Also known as DHR or GLGF)
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