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Fbxl13 F-box and leucine-rich repeat protein 13 [ Mus musculus (house mouse) ]

Gene ID: 320118, updated on 23-Jun-2021

Summary

Official Symbol
Fbxl13provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 13provided by MGI
Primary source
MGI:MGI:2443416
See related
Ensembl:ENSMUSG00000048520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921539K22Rik
Expression
Biased expression in testis adult (RPKM 14.6) and ovary adult (RPKM 0.6) See more
Orthologs
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Genomic context

See Fbxl13 in Genome Data Viewer
Location:
5; 5 A3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21688845..21850696, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21483847..21645698, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (20989665..21151423, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 146 Neighboring gene VISTA enhancer mm186 Neighboring gene fibrinogen-like protein 2 Neighboring gene family with sequence similarity 185, member A Neighboring gene leucine rich repeat containing 17 Neighboring gene predicted gene 6543 Neighboring gene protein archease pseudogene Neighboring gene armadillo repeat containing 10 Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene microRNA 12197

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein regulatory complex subunit 6
Names
F-box/LRR-repeat protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199632.1NP_001186561.1  dynein regulatory complex subunit 6 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform a).
    Source sequence(s)
    BB614373, BC145291, CO797010
    UniProtKB/TrEMBL
    B7ZNK1
    Conserved Domains (5) summary
    cd09293
    Location:536752
    AMN1; Antagonist of mitotic exit network protein 1
    sd00033
    Location:486523
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:537564
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:240286
    F-box-like; F-box-like
    cl06673
    Location:5492
    Extradiol_Dioxygenase_3A_like; Subunit A of Class III extradiol dioxygenases
  2. NM_177076.4NP_796050.2  dynein regulatory complex subunit 6 isoform b

    See identical proteins and their annotated locations for NP_796050.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.
    Source sequence(s)
    BB614373, BC145292, CO797010
    Consensus CDS
    CCDS51429.1
    UniProtKB/Swiss-Prot
    Q8CDU4
    UniProtKB/TrEMBL
    B7ZNK2
    Related
    ENSMUSP00000052716.5, ENSMUST00000051358.11
    Conserved Domains (5) summary
    cd09293
    Location:503719
    AMN1; Antagonist of mitotic exit network protein 1
    sd00033
    Location:453470
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:504531
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:240286
    F-box-like; F-box-like
    cl06673
    Location:5492
    Extradiol_Dioxygenase_3A_like; Subunit A of Class III extradiol dioxygenases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    21688845..21850696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535728.3XP_006535791.1  dynein regulatory complex subunit 6 isoform X3

    Conserved Domains (4) summary
    cd09293
    Location:536752
    AMN1; Antagonist of mitotic exit network protein 1
    sd00033
    Location:486523
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:537564
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:240284
    F-box-like
  2. XM_011249772.2XP_011248074.1  dynein regulatory complex subunit 6 isoform X5

    Conserved Domains (2) summary
    cd09293
    Location:91223
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:5479
    LRR_AMN1; leucine-rich repeat [structural motif]
  3. XM_011249771.4XP_011248073.1  dynein regulatory complex subunit 6 isoform X4

    Conserved Domains (3) summary
    cd09293
    Location:211380
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:185211
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:145189
    F-box-like
  4. XM_011249770.4XP_011248072.1  dynein regulatory complex subunit 6 isoform X2

    Conserved Domains (3) summary
    cd09293
    Location:306572
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:331356
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:240284
    F-box-like
  5. XM_011249769.3XP_011248071.1  dynein regulatory complex subunit 6 isoform X1

    Conserved Domains (3) summary
    cd09293
    Location:306475
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:280306
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:240284
    F-box-like
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