Zdhhc17 zinc finger, DHHC domain containing 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zdhhc17provided by MGI
Official Full Name: zinc finger, DHHC domain containing 17provided by MGI
Primary source: MGI:MGI:2445110
See related: Ensembl:ENSMUSG00000035798 AllianceGenome:MGI:2445110
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hip14; DHHC-17; A230053P19Rik; D130071N24Rik
Summary: Enables palmitoyltransferase activity and signaling receptor binding activity. Involved in axonogenesis; peptidyl-L-cysteine S-palmitoylation; and regulation of signal transduction. Acts upstream of or within protein palmitoylation. Located in Golgi apparatus. Is expressed in several structures, including early conceptus; heart; and oocyte. Used to study Huntington's disease. Orthologous to human ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 24.0), CNS E18 (RPKM 21.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D1; 10 57.86 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (110777640..110848587, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (110941779..111010066, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction.
Title: S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction.
Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17.
Title: Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17.
These data suggest that HIP14 is essential for maintenance of life and neuronal integrity in the adult mouse.
Title: Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice.
The findings of this study identify ZDHHC17 as an important upstream factor of ERK1/2 to regulate the interaction between TrkA and tubulin during neuronal development.
Title: ZDHHC17 promotes axon outgrowth by regulating TrkA-tubulin complex formation.
Data show that the ankyrin repeat (AR) domains of S-acyltransferases zDHHC17 and zDHHC13 recognize peptide sequence in several unrelated proteins.
Title: Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases.
Loss of Hip14 and Hip14l leads to early embryonic lethality at day embryonic day 10-11 due to failed chorioallantoic fusion.
Title: Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development.
Data indicate that thioesterases APT1/APT2 depalmitoylate nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) and zDHHC17 is the strongest candidate palmitoyltransferase for NMNAT2.
Title: Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2).
In the absence of HIP14, striatal neurons become dysfunctional, leading to impaired motor behavior.
Title: Dysregulated striatal neuronal processing and impaired motor behavior in mice lacking huntingtin interacting protein 14 (HIP14).
The constitutive absence of Hip14/DHHC17 results in major neurophysiological deficits and associated cognitive dysfunction.
Title: Memory and synaptic deficits in Hip14/DHHC17 knockout mice.
altered palmitoylation mediated by HIP14 may contribute to HD.
Title: Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Rat210 (e-PCR), detects polymorphism
- UniSTS:228159

NoName (e-PCR)
- UniSTS:236456

BB187739 (e-PCR)
- UniSTS:185851

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-cysteine S-myristoyltransferase activity	IC Inferred by Curator more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IC Inferred by Curator more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-stearoyltransferase activity	IC Inferred by Curator more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-L-cysteine S-palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of modification of synapse structure, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of synapse structure, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotrophin TRK receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of programmed cell death	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in perforant pathway to dendrate granule cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in perforant pathway to dendrate granule cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC17

Names: DHHC domain-containing cysteine-rich protein 17; acyltransferase ZDHHC17; acyltransferase ZDHHC7; huntingtin interacting protein 14; zinc finger DHHC domain-containing protein 17

NP_001346551.1

EC 2.3.1.225

NP_001346553.1

EC 2.3.1.225

NP_766142.2

EC 2.3.1.225

XP_030100985.1

EC 2.3.1.225

XP_036011712.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359622.1 → NP_001346551.1 palmitoyltransferase ZDHHC17 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a shorter 5' UTR than variant 1, and initiates translation at a downstream start codon, compared to variant 1. This variant intiates transcription from a major transcription start site, as determined by CAGE data. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AK038670, AK046891, AW911453, BE955669, BQ560505

UniProtKB/TrEMBL

Q0VFY6

Conserved Domains (3) summary

cd00204
Location:77 → 192

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:146 → 177

ANK; ANK repeat [structural motif]

pfam01529
Location:428 → 558

zf-DHHC; DHHC palmitoyltransferase
NM_001359624.1 → NP_001346553.1 palmitoyltransferase ZDHHC17 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site, resulting in translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning results in translation initiation at the downstream start codon to encode an isoform (3) that has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK039575, AW911453, BC027101, BE955669

Conserved Domains (1) summary

pfam01529
Location:166 → 296

DHHC; DHHC palmitoyltransferase
NM_172554.2 → NP_766142.2 palmitoyltransferase ZDHHC17 isoform 1

See identical proteins and their annotated locations for NP_766142.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK039575, AK046891, AW911453, BC027101, BC051527

Consensus CDS

CCDS56748.1

UniProtKB/Swiss-Prot

Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6

Related

ENSMUSP00000043279.8, ENSMUST00000041723.15

Conserved Domains (4) summary

PHA03095
Location:100 → 352

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:156 → 187

ANK; ANK repeat [structural motif]

pfam01529
Location:438 → 568

DHHC; DHHC palmitoyltransferase

pfam12796
Location:161 → 255

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

110777640..110848587 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155819.1 → XP_036011712.1 palmitoyltransferase ZDHHC17 isoform X1

Conserved Domains (1) summary

pfam01529
Location:186 → 316

DHHC; DHHC palmitoyltransferase
XM_030245125.2 → XP_030100985.1 palmitoyltransferase ZDHHC17 isoform X1

Conserved Domains (1) summary

pfam01529
Location:186 → 316

DHHC; DHHC palmitoyltransferase