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Cfap91 cilia and flagella associated protein 91 [ Mus musculus (house mouse) ]

Gene ID: 320214, updated on 5-Mar-2024

Summary

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Official Symbol
Cfap91provided by MGI
Official Full Name
cilia and flagella associated protein 91provided by MGI
Primary source
MGI:MGI:2443598
See related
Ensembl:ENSMUSG00000022805 AllianceGenome:MGI:2443598
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aat1; Maats1; Spata26; 4932425I24Rik
Summary
Predicted to be located in cell projection; cytoskeleton; and mitochondrion. Is expressed in choroid invagination; diencephalon roof plate; lung; and metencephalon part of 4th ventricle choroid plexus. Human ortholog(s) of this gene implicated in spermatogenic failure 51. Orthologous to human CFAP91 (cilia and flagella associated protein 91). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 9.6), placenta adult (RPKM 0.9) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
16 B3; 16 26.71 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (38118116..38162222, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (38297754..38341860, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene glycogen synthase kinase 3 beta Neighboring gene STARR-seq mESC enhancer starr_40810 Neighboring gene predicted gene, 25617 Neighboring gene STARR-seq mESC enhancer starr_40811 Neighboring gene STARR-seq mESC enhancer starr_40812 Neighboring gene nuclear receptor subfamily 1, group I, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E9163 Neighboring gene cytochrome c oxidase assembly protein 17, copper chaperone Neighboring gene popeye domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase. Yukitake H, et al. J Biol Chem, 2002 Nov 22. PMID 12223483
  2. CFAP61 is required for sperm flagellum formation and male fertility in human and mouse. Liu S, et al. Development, 2021 Dec 1. PMID 34792097
  3. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonemal central apparatus assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cilia- and flagella-associated protein 91
Names
AAT-1
AMY-1-associating protein expressed in testis 1 homolog
MYCBP-associated, testis expressed 1
MYCBP/AMY-1-associated testis-expressed protein 1
protein MAATS1
spermatogenesis associated 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081025.1 → NP_001074494.1  cilia- and flagella-associated protein 91

    See identical proteins and their annotated locations for NP_001074494.1

    Status: PROVISIONAL

    Source sequence(s)
    AC154809
    Consensus CDS
    CCDS37341.1
    UniProtKB/Swiss-Prot
    E9PZ32, E9QND1, Q8BRC6
    Related
    ENSMUSP00000023501.9, ENSMUST00000023501.16
    Conserved Domains (1) summary
    pfam14738
    Location:190 → 342
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    38118116..38162222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522245.3 → XP_006522308.1  cilia- and flagella-associated protein 91 isoform X1

    Conserved Domains (2) summary
    pfam14738
    Location:71 → 223
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
    pfam17380
    Location:398 → 571
    DUF5401; Family of unknown function (DUF5401)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177104.1: Suppressed sequence

    Description
    NM_177104.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BRC6.3 GenPept UniProtKB/Swiss-Prot:Q8BRC6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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