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Ric3 RIC3 acetylcholine receptor chaperone [ Mus musculus (house mouse) ]

Gene ID: 320360, updated on 21-Apr-2024

Summary

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Official Symbol
Ric3provided by MGI
Official Full Name
RIC3 acetylcholine receptor chaperoneprovided by MGI
Primary source
MGI:MGI:2443887
See related
Ensembl:ENSMUSG00000048330 AllianceGenome:MGI:2443887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E130307J04Rik
Summary
Enables protein folding chaperone. Acts upstream of or within cellular protein-containing complex assembly. Located in endoplasmic reticulum. Is integral component of membrane. Orthologous to human RIC3 (RIC3 acetylcholine receptor chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 12.0), cortex adult (RPKM 7.6) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E3; 7 57.21 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (108633475..108682538, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109034268..109083432, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39067 Neighboring gene predicted gene, 32309 Neighboring gene TUB bipartite transcription factor Neighboring gene predicted gene, 25450 Neighboring gene STARR-seq mESC enhancer starr_19793 Neighboring gene predicted gene 44781 Neighboring gene LIM domain only 1 Neighboring gene STARR-seq mESC enhancer starr_19794 Neighboring gene predicted gene, 32563

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation. Ben-David Y, et al. Int Immunopharmacol, 2020 Jun. PMID 32179243
  2. RIC-3 expression and splicing regulate nAChR functional expression. Ben-David Y, et al. Mol Brain, 2016 Apr 29. PMID 27129882, Free PMC Article
  3. Ric-3 promotes alpha7 nicotinic receptor assembly and trafficking through the ER subcompartment of dendrites. Alexander JK, et al. J Neurosci, 2010 Jul 28. PMID 20668195, Free PMC Article
  4. Mouse RIC-3, an endoplasmic reticulum chaperone, promotes assembly of the alpha7 acetylcholine receptor through a cytoplasmic coiled-coil domain. Wang Y, et al. J Neurosci, 2009 Oct 7. PMID 19812337, Free PMC Article
  5. Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of α7 Nicotinic Receptors in Mouse Brain? Deshpande A, et al. Biomolecules, 2020 Mar 19. PMID 32204458, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of alpha7 Nicotinic Receptors in Mouse Brain?
    Title: Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of α7 Nicotinic Receptors in Mouse Brain?
  2. RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation.
    Title: RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation.
  3. Regulation of expression level and splicing of RIC-3 in brain and in immune cells following inflammation enables regulation of nicotinic acetylcholine receptor functional expression.
    Title: RIC-3 expression and splicing regulate nAChR functional expression.
  4. In neurons, Ric-3 ER retention appears to promote transport within the dendritic ER subcompartment, thereby restricting 7 trafficking to dendrites and preventing axonal transport.
    Title: Ric-3 promotes alpha7 nicotinic receptor assembly and trafficking through the ER subcompartment of dendrites.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein RIC-3
Names
resistance to inhibitors of cholinesterase 3 homolog
resistant to inhibitor of cholinesterase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038624.1 → NP_001033713.1  protein RIC-3 isoform a precursor

    See identical proteins and their annotated locations for NP_001033713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform a).
    Source sequence(s)
    BC059258, BY241896, BY279630
    Consensus CDS
    CCDS21733.1
    UniProtKB/Swiss-Prot
    Q6PCM7, Q8BPM6, Q8C4G2
    Related
    ENSMUSP00000056990.7, ENSMUST00000055993.13
    Conserved Domains (1) summary
    pfam15361
    Location:19 → 164
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  2. NM_001311161.1 → NP_001298090.1  protein RIC-3 isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter compared to isoform a.
    Source sequence(s)
    AK138641, BC059258, BY241896
    Consensus CDS
    CCDS80778.1
    UniProtKB/TrEMBL
    D3YTZ9
    Related
    ENSMUSP00000112788.2, ENSMUST00000120876.2
    Conserved Domains (1) summary
    pfam15361
    Location:19 → 164
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  3. NM_178780.3 → NP_848895.2  protein RIC-3 isoform b precursor

    See identical proteins and their annotated locations for NP_848895.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site used in variant 1 that leads to a frameshift. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK149334, BY279630
    UniProtKB/Swiss-Prot
    Q8BPM6
    Conserved Domains (1) summary
    pfam15361
    Location:19 → 164
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    108633475..108682538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507942.3 → XP_006508005.1  protein RIC-3 isoform X1

    See identical proteins and their annotated locations for XP_006508005.1

    UniProtKB/Swiss-Prot
    Q8BPM6

  2. XM_006507943.5 → XP_006508006.1  protein RIC-3 isoform X1

    See identical proteins and their annotated locations for XP_006508006.1

    UniProtKB/Swiss-Prot
    Q8BPM6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BPM6.2 GenPept UniProtKB/Swiss-Prot:Q8BPM6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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