Fastkd1 FAST kinase domains 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fastkd1provided by MGI
Official Full Name: FAST kinase domains 1provided by MGI
Primary source: MGI:MGI:2444596
See related: Ensembl:ENSMUSG00000027086 AllianceGenome:MGI:2444596
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1800; 5330408N05Rik
Summary: Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing and regulation of mitochondrial mRNA stability. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human FASTKD1 (FAST kinase domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 4.3), CNS E11.5 (RPKM 3.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C2; 2 40.93 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (69517159..69543875, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (69686820..69712606, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FASTKD1 supports mitochondrial homeostasis and plays a critical role against oxidant-induced death.
Title: The novel cyclophilin-D-interacting protein FASTKD1 protects cells against oxidative stress-induced cell death.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitochondrial RNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial mRNA stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: FAST kinase domain-containing protein 1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177244.3 → NP_796218.2 FAST kinase domain-containing protein 1, mitochondrial

See identical proteins and their annotated locations for NP_796218.2

Status: PROVISIONAL

Source sequence(s)

BC075689

Consensus CDS

CCDS16096.1

UniProtKB/Swiss-Prot

A2AR00, B0R0D3, Q5DTU7, Q6DI86, Q6IS39, Q8BSV8, Q8C429, Q8R1N6

Related

ENSMUSP00000072896.7, ENSMUST00000073152.13

Conserved Domains (3) summary

smart00952
Location:763 → 821

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:560 → 628

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:648 → 729

FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

69517159..69543875 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162311.1 → XP_036018204.1 FAST kinase domain-containing protein 1, mitochondrial isoform X1

Conserved Domains (3) summary

smart00952
Location:635 → 693

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:432 → 500

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:519 → 601

FAST_2; FAST kinase-like protein, subdomain 2