Format

Send to:

Choose Destination

Atp11c ATPase, class VI, type 11C [ Mus musculus (house mouse) ]

Gene ID: 320940, updated on 23-Jun-2021

Summary

Official Symbol
Atp11cprovided by MGI
Official Full Name
ATPase, class VI, type 11Cprovided by MGI
Primary source
MGI:MGI:1859661
See related
Ensembl:ENSMUSG00000062949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
I; Ig; AI315324; A330005H02Rik
Expression
Broad expression in CNS E14 (RPKM 7.2), whole brain E14.5 (RPKM 6.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Atp11c in Genome Data Viewer
Location:
X; X A6
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (59268643..59450041, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (60223283..60404853, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (57476467..57657156, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5637 Neighboring gene mcf.2 transforming sequence Neighboring gene predicted gene, 22287 Neighboring gene microRNA 505 Neighboring gene predicted gene 8144 Neighboring gene predicted gene 7073

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117487

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylethanolamine flippase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine flippase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pre-B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phospholipid-transporting ATPase 11C
Names
Atpase 11c, p type
P4-ATPase flippase complex alpha subunit ATP11C
probable phospholipid-transporting ATPase 11C
NP_001001798.1
NP_001032952.1
NP_001345931.1
XP_006528153.1
XP_006528154.1
XP_006528156.1
XP_006528158.1
XP_006528159.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001798.3NP_001001798.1  phospholipid-transporting ATPase 11C isoform b

    Status: VALIDATED

    Source sequence(s)
    BC106087, BY017646, CO042050, CU682339
    Consensus CDS
    CCDS40987.1
    UniProtKB/Swiss-Prot
    Q9QZW0
    UniProtKB/TrEMBL
    E9QKK8
    Related
    ENSMUSP00000033480.7, ENSMUST00000033480.13
    Conserved Domains (8) summary
    TIGR01652
    Location:401088
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:97182
    E1-E2_ATPase; E1-E2 ATPase
    pfam04547
    Location:260374
    Anoctamin; Calcium-activated chloride channel
    pfam13246
    Location:468572
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:3790
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:8421089
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl14615
    Location:555674
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl21460
    Location:811840
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. NM_001037863.2NP_001032952.1  phospholipid-transporting ATPase 11C isoform a

    See identical proteins and their annotated locations for NP_001032952.1

    Status: VALIDATED

    Source sequence(s)
    BC106087, BY017646, CO042050, CU682339
    Consensus CDS
    CCDS40988.1
    UniProtKB/Swiss-Prot
    Q9QZW0
    Related
    ENSMUSP00000099066.3, ENSMUST00000101527.3
    Conserved Domains (2) summary
    cd02073
    Location:42974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam02322
    Location:9931083
    Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
  3. NM_001359002.1NP_001345931.1  phospholipid-transporting ATPase 11C isoform c

    Status: VALIDATED

    Source sequence(s)
    AL670778, BX284683, CO042050, CU682339
    Conserved Domains (1) summary
    cd02073
    Location:42974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    59268643..59450041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528091.5XP_006528154.1  phospholipid-transporting ATPase 11C isoform X1

    See identical proteins and their annotated locations for XP_006528154.1

    UniProtKB/Swiss-Prot
    Q9QZW0
    Conserved Domains (2) summary
    cd02073
    Location:42974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam02322
    Location:9931083
    Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
  2. XM_006528090.5XP_006528153.1  phospholipid-transporting ATPase 11C isoform X1

    See identical proteins and their annotated locations for XP_006528153.1

    UniProtKB/Swiss-Prot
    Q9QZW0
    Conserved Domains (2) summary
    cd02073
    Location:42974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam02322
    Location:9931083
    Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
  3. XM_006528095.4XP_006528158.1  phospholipid-transporting ATPase 11C isoform X3

    See identical proteins and their annotated locations for XP_006528158.1

    Conserved Domains (2) summary
    cd02073
    Location:42974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam02322
    Location:9931083
    Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
  4. XM_006528093.3XP_006528156.1  phospholipid-transporting ATPase 11C isoform X2

    See identical proteins and their annotated locations for XP_006528156.1

    Conserved Domains (1) summary
    cd02073
    Location:42974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  5. XM_006528096.3XP_006528159.1  phospholipid-transporting ATPase 11C isoform X3

    See identical proteins and their annotated locations for XP_006528159.1

    Conserved Domains (2) summary
    cd02073
    Location:42974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam02322
    Location:9931083
    Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

RNA

  1. XR_001782750.2 RNA Sequence

  2. XR_004940343.1 RNA Sequence

Support Center