U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atp11c ATPase, class VI, type 11C [ Mus musculus (house mouse) ]

Gene ID: 320940, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Atp11cprovided by MGI
Official Full Name
ATPase, class VI, type 11Cprovided by MGI
Primary source
MGI:MGI:1859661
See related
Ensembl:ENSMUSG00000062949 AllianceGenome:MGI:1859661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ig; A330005H02Rik
Summary
Predicted to enable phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Involved in phospholipid translocation; positive regulation of B cell differentiation; and pre-B cell differentiation. Predicted to be integral component of plasma membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; recycling endosome; and trans-Golgi network. Is expressed in choroid invagination; diencephalon roof plate; and metencephalon part of 4th ventricle choroid plexus. Human ortholog(s) of this gene implicated in X-linked congenital hemolytic anemia. Orthologous to human ATP11C (ATPase phospholipid transporting 11C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 7.2), whole brain E14.5 (RPKM 6.7) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
X A6; X 33.5 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (59268643..59450041, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (60223283..60404853, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5637 Neighboring gene mcf.2 transforming sequence Neighboring gene STARR-seq mESC enhancer starr_47238 Neighboring gene STARR-seq mESC enhancer starr_47239 Neighboring gene STARR-seq mESC enhancer starr_47240 Neighboring gene STARR-seq mESC enhancer starr_47242 Neighboring gene predicted gene, 22287 Neighboring gene microRNA 505 Neighboring gene predicted gene 8144 Neighboring gene predicted gene 7073

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes. de Waart DR, et al. Hepatology, 2016 Jul. PMID 26926206, Free PMC Article
  2. ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes. Yabas M, et al. PLoS One, 2016. PMID 26799398, Free PMC Article
  3. ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function. Naik J, et al. Dig Dis, 2015. PMID 26045263
  4. Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span. Yabas M, et al. J Biol Chem, 2014 Jul 11. PMID 24898253, Free PMC Article
  5. The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane. Takayama M, et al. J Cell Sci, 2019 Sep 2. PMID 31371488

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATP11C promotes the differentiation of pre-B cells into immature B cells but does not affect their IL-7-dependent proliferation.
    Title: ATP11C promotes the differentiation of pre-B cells into immature B cells but does not affect their IL-7-dependent proliferation.
  2. The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane.
    Title: The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane.
  3. ATP11A and ATP11C in precursor B cells are essential for rapidly internalizing PtdSer from the cell surface to prevent the cells' engulfment by macrophages.
    Title: Phospholipid flippases enable precursor B cells to flee engulfment by macrophages.
  4. essential for basolateral membrane localization of multiple bile salt transport proteins in central hepatocytes
    Title: Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice.
  5. a mutation in ATP11C resulted in diminished flippase activity in immune cells, suggesting ATP11C is a flippase that selectively transports phosphatidylserine and phosphatidylethanolamine from the outer leaflet of the plasma membrane to the inner leaflet.
    Title: ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes.
  6. an essential role for ATP11C in erythrocyte morphology and survival and provide a new candidate for the rare inherited blood disorder stomatocytosis with uncompensated anemia.
    Title: Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span.
  7. Mutation of the X-linked gene Atp11c, which encodes a paralogous P4-type ATPase, precludes B-cell development in the adult bone marrow, but also causes hyperbilirubinemia.
    Title: X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C.
  8. A defect is ATP11C results inlower B-cell phosphatidylserine flippase activity and disrupts B-cell development and antibody production and also causes hepatocellular carcinoma.
    Title: ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes.
  9. ATP11C is redundant during B cell development in the fetal liver but essential in the context of adult bone marrow where it is required for optiml responses to IL-7 and sustained expression of Ebf1.
    Title: The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC117487

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylethanolamine flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid translocation ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pre-B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phospholipid-transporting ATPase 11C
Names
Atpase 11c, p type
P4-ATPase flippase complex alpha subunit ATP11C
probable phospholipid-transporting ATPase 11C
NP_001001798.1
NP_001032952.1
NP_001345931.1
XP_006528153.1
XP_006528154.1
XP_006528156.1
XP_006528158.1
XP_006528159.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001798.3 → NP_001001798.1  phospholipid-transporting ATPase 11C isoform b

    Status: VALIDATED

    Source sequence(s)
    BC106087, BY017646, CO042050, CU682339
    Consensus CDS
    CCDS40987.1
    UniProtKB/TrEMBL
    E9QKK8, F6Q8D3
    Related
    ENSMUSP00000033480.7, ENSMUST00000033480.13
    Conserved Domains (8) summary
    TIGR01652
    Location:40 → 1088
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:97 → 182
    E1-E2_ATPase; E1-E2 ATPase
    pfam04547
    Location:260 → 374
    Anoctamin; Calcium-activated chloride channel
    pfam13246
    Location:468 → 572
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:37 → 90
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:842 → 1089
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl14615
    Location:555 → 674
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl21460
    Location:811 → 840
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_001037863.2 → NP_001032952.1  phospholipid-transporting ATPase 11C isoform a

    See identical proteins and their annotated locations for NP_001032952.1

    Status: VALIDATED

    Source sequence(s)
    BC106087, BY017646, CO042050, CU682339
    Consensus CDS
    CCDS40988.1
    UniProtKB/Swiss-Prot
    Q3KQR4, Q9QZW0
    UniProtKB/TrEMBL
    F6Q8D3
    Related
    ENSMUSP00000099066.3, ENSMUST00000101527.3
    Conserved Domains (2) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam02322
    Location:993 → 1083
    Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

  3. NM_001359002.1 → NP_001345931.1  phospholipid-transporting ATPase 11C isoform c

    Status: VALIDATED

    Source sequence(s)
    AL670778, BX284683, CO042050, CU682339
    UniProtKB/TrEMBL
    F6Q8D3
    Conserved Domains (1) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    59268643..59450041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528091.5 → XP_006528154.1  phospholipid-transporting ATPase 11C isoform X1

    See identical proteins and their annotated locations for XP_006528154.1

    UniProtKB/Swiss-Prot
    Q3KQR4, Q9QZW0
    UniProtKB/TrEMBL
    F6Q8D3
    Conserved Domains (2) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam02322
    Location:993 → 1083
    Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

  2. XM_006528090.5 → XP_006528153.1  phospholipid-transporting ATPase 11C isoform X1

    See identical proteins and their annotated locations for XP_006528153.1

    UniProtKB/Swiss-Prot
    Q3KQR4, Q9QZW0
    UniProtKB/TrEMBL
    F6Q8D3
    Conserved Domains (2) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam02322
    Location:993 → 1083
    Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

  3. XM_006528095.4 → XP_006528158.1  phospholipid-transporting ATPase 11C isoform X3

    See identical proteins and their annotated locations for XP_006528158.1

    UniProtKB/TrEMBL
    F6Q8D3
    Conserved Domains (2) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam02322
    Location:993 → 1083
    Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

  4. XM_006528093.3 → XP_006528156.1  phospholipid-transporting ATPase 11C isoform X2

    See identical proteins and their annotated locations for XP_006528156.1

    UniProtKB/TrEMBL
    F6Q8D3
    Conserved Domains (1) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  5. XM_006528096.3 → XP_006528159.1  phospholipid-transporting ATPase 11C isoform X3

    See identical proteins and their annotated locations for XP_006528159.1

    UniProtKB/TrEMBL
    F6Q8D3
    Conserved Domains (2) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam02322
    Location:993 → 1083
    Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

RNA

  1. XR_001782750.2 RNA Sequence

  2. XR_004940343.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZW0.2 GenPept UniProtKB/Swiss-Prot:Q9QZW0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous