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CG11164 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32323, updated on 10-May-2024

Summary

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Official Symbol
CG11164provided by FlyBase
Primary source
FLYBASE:FBgn0030507
Locus tag
Dmel_CG11164
See related
AllianceGenome:FB:FBgn0030507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG11164
Summary
Predicted to be involved in RNA catabolic process and ribonucleotide metabolic process. Predicted to be part of ribonuclease H2 complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including anterior endoderm anlage; embryonic brain; extended germ band embryo; germ layer; and somatic precursor cell. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2B (ribonuclease H2 subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CG11164 in Genome Data Viewer
Location:
12B2-12B2; 1-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13668014..13669573)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13562047..13563606)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene NFAT nuclear factor Neighboring gene DNA ligase 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. End-joining repair of double-strand breaks in Drosophila melanogaster is largely DNA ligase IV independent. McVey M, et al. Genetics, 2004 Dec. PMID 15611176, Free PMC Article
  2. Non-random genomic integration - an intrinsic property of retrogenes in Drosophila? Metta M, et al. BMC Evol Biol, 2010 Apr 28. PMID 20426838, Free PMC Article
  3. Promoter-Proximal Chromatin Domain Insulator Protein BEAF Mediates Local and Long-Range Communication with a Transcription Factor and Directly Activates a Housekeeping Promoter in Drosophila. Dong Y, et al. Genetics, 2020 May. PMID 32179582, Free PMC Article
  4. Genome-wide mapping of boundary element-associated factor (BEAF) binding sites in Drosophila melanogaster links BEAF to transcription. Jiang N, et al. Mol Cell Biol, 2009 Jul. PMID 19380483, Free PMC Article
  5. Expression profiling of glial genes during Drosophila embryogenesis. Altenhein B, et al. Dev Biol, 2006 Aug 15. PMID 16762338

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease H2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease H2 complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG11164-PA
CG11164-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13668014..13669573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298291.1 → NP_001285220.1  uncharacterized protein Dmel_CG11164, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285220.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4LU33, Q9VYA4
    Conserved Domains (1) summary
    cd09270
    Location:39 → 338
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

  2. NM_132680.3 → NP_572908.2  uncharacterized protein Dmel_CG11164, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572908.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4LU33, Q9VYA4
    Related
    FBpp0073640
    Conserved Domains (1) summary
    cd09270
    Location:39 → 338
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SYN7 Q8SYN7
Q9VYA4 Q9VYA4

Gene LinkOut

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