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Pdcd4 Programmed cell death 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32337, updated on 10-May-2024

Summary

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Official Symbol
Pdcd4provided by FlyBase
Official Full Name
Programmed cell death 4provided by FlyBase
Primary source
FLYBASE:FBgn0030520
Locus tag
Dmel_CG10990
See related
AllianceGenome:FB:FBgn0030520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10990; Dmel\CG10990; pdcd4
Summary
Involved in germarium-derived female germ-line cyst formation and positive regulation of stem cell differentiation. Located in cytosol. Is expressed in several structures, including adult brain; endoderm anlage; extended germ band embryo; germ layer; and gonad. Orthologous to human PDCD4 (programmed cell death 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pdcd4 in Genome Data Viewer
Location:
12B4-12B10; 1-45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13745577..13755406, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13639610..13649439, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Gamma-tubulin ring protein 91 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42861 Neighboring gene antisense RNA:CR43833 Neighboring gene uncharacterized protein Neighboring gene Rtc1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Highly effective proximate labeling in Drosophila. Zhang B, et al. G3 (Bethesda), 2021 May 7. PMID 33724396, Free PMC Article
  2. An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4. Fehler O, et al. Nucleic Acids Res, 2014. PMID 25190455, Free PMC Article
  3. The insulin receptor cellular IRES confers resistance to eIF4A inhibition. Olson CM, et al. Elife, 2013 Jul 16. PMID 23878722, Free PMC Article
  4. Quantitative genomics of locomotor behavior in Drosophila melanogaster. Jordan KW, et al. Genome Biol, 2007. PMID 17708775, Free PMC Article
  5. Drosophila sperm development and intercellular cytoplasm sharing through ring canals do not require an intact fusome. Kaufman RS, et al. Development, 2020 Nov 15. PMID 33033119, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pdcd4 promotes the differentiation of germline stem cells daughter cells by relieving the eIF4A-mediated inhibition of Bam. [Pdcd4]
    Title: Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in germarium-derived female germ-line cyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
programmed cell death 4
Names
CG10990-PA
CG10990-PB
CG10990-PC
CG10990-PD
Pdcd4-PA
Pdcd4-PB
Pdcd4-PC
Pdcd4-PD
programmed cell death 4 ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13745577..13755406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272604.1 → NP_001259533.1  programmed cell death 4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259533.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VY91
    Conserved Domains (2) summary
    smart00544
    Location:197 → 308
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02847
    Location:363 → 476
    MA3; MA3 domain

  2. NM_001103507.3 → NP_001096977.1  programmed cell death 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096977.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VY91
    Conserved Domains (2) summary
    smart00544
    Location:197 → 308
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02847
    Location:363 → 476
    MA3; MA3 domain

  3. NM_001272603.1 → NP_001259532.1  programmed cell death 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259532.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VY91
    Conserved Domains (2) summary
    smart00544
    Location:197 → 308
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02847
    Location:363 → 476
    MA3; MA3 domain

  4. NM_132690.4 → NP_572918.1  programmed cell death 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572918.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VY91
    Related
    FBpp0073671
    Conserved Domains (2) summary
    smart00544
    Location:197 → 308
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02847
    Location:363 → 476
    MA3; MA3 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VY91 Q9VY91

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