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pdgy pudgy [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32426, updated on 10-May-2024

Summary

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Official Symbol
pdgyprovided by FlyBase
Official Full Name
pudgyprovided by FlyBase
Primary source
FLYBASE:FBgn0027601
Locus tag
Dmel_CG9009
See related
AllianceGenome:FB:FBgn0027601
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH02901; CG9009; Dmel\CG9009; Pdgy
Summary
Enables long-chain fatty acid-CoA ligase activity. Involved in fatty-acyl-CoA biosynthetic process; long-chain fatty acid metabolic process; and triglyceride catabolic process. Located in mitochondrion. Is expressed in several structures, including extended germ band embryo; fat body; germ layer; presumptive embryonic/larval system; and stage 5 embryo. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See pdgy in Genome Data Viewer
Location:
13A1-13A1; 1-49 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14933670..14953532, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14827703..14847565, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Flotillin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44831 Neighboring gene uncharacterized protein Neighboring gene ether a go-go

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The acyl-CoA Synthetase, pudgy, Promotes Sleep and Is Required for the Homeostatic Response to Sleep Deprivation. Thimgan MS, et al. Front Endocrinol (Lausanne), 2018. PMID 30186232, Free PMC Article
  2. Insulin signaling regulates fatty acid catabolism at the level of CoA activation. Xu X, et al. PLoS Genet, 2012 Jan. PMID 22275878, Free PMC Article
  3. Selective sweep in the Flotillin-2 region of European Drosophila melanogaster. Werzner A, et al. PLoS One, 2013. PMID 23437190, Free PMC Article
  4. The microRNA miR-33 is a pleiotropic regulator of metabolic and developmental processes in Drosophila melanogaster. Clerbaux LA, et al. Dev Dyn, 2021 Nov. PMID 33840153
  5. The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. Jünger MA, et al. J Biol, 2003. PMID 12908874, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty-acyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pudgy
Names
CG9009-PA
CG9009-PB
CG9009-PC
CG9009-PD
long chain fatty acid CoA ligase
pdgy-PA
pdgy-PB
pdgy-PC
pdgy-PD
NP_001188590.1
NP_001245673.1
NP_001285257.1
NP_572988.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14933670..14953532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201661.2 → NP_001188590.1  pudgy, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188590.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXZ8, Q9Y158
    Conserved Domains (2) summary
    cd05911
    Location:99 → 587
    Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
    COG0318
    Location:77 → 595
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]

  2. NM_001298328.1 → NP_001285257.1  pudgy, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285257.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXZ8, Q9Y158
    Conserved Domains (2) summary
    cd05911
    Location:99 → 587
    Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
    COG0318
    Location:77 → 595
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]

  3. NM_001258744.1 → NP_001245673.1  pudgy, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245673.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXZ8, Q9Y158
    Conserved Domains (2) summary
    cd05911
    Location:99 → 587
    Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
    COG0318
    Location:77 → 595
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]

  4. NM_132760.5 → NP_572988.1  pudgy, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572988.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXZ8, Q9Y158
    Related
    FBpp0073789
    Conserved Domains (2) summary
    cd05911
    Location:99 → 587
    Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
    COG0318
    Location:77 → 595
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXZ8 Q9VXZ8

Gene LinkOut

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