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ND-B18 NADH dehydrogenase (ubiquinone) B18 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32434, updated on 4-Apr-2024

Summary

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Official Symbol
ND-B18provided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) B18 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0030605
Locus tag
Dmel_CG5548
See related
AllianceGenome:FB:FBgn0030605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5548; Dmel\CG5548; dNDUFB7; NB8M; NDUFB7
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be part of mitochondrial respiratory chain complex I. Is expressed in adult head and adult heart. Orthologous to human NDUFB7 (NADH:ubiquinone oxidoreductase subunit B7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ND-B18 in Genome Data Viewer
Location:
13A8-13A8; 1-49 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15063733..15064926)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14957766..14958959)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene highwire Neighboring gene ben Neighboring gene uncharacterized protein Neighboring gene opossum Neighboring gene doppelganger von brummer Neighboring gene Lipid storage droplet-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complex-I-ty in aging. Hur JH, et al. J Bioenerg Biomembr, 2014 Aug. PMID 24961226, Free PMC Article
  2. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article
  3. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article
  4. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article
  5. An antibody toolbox to track complex I assembly defines AIF's mitochondrial function. Murari A, et al. J Cell Biol, 2020 Oct 5. PMID 32936885, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADH dehydrogenase (ubiquinone) B18 subunit
Names
CG5548-PA
CG5548-PB
CG5548-PC
NADH ubiquinone oxidoreductase B18
NADH-ubiquinone oxidoreductase B18 subunit
NADH:ubiquinone oxidoreductase B18 subunit
ND-B18-PA
ND-B18-PB
ND-B18-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15063733..15064926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298331.1 → NP_001285260.1  NADH dehydrogenase (ubiquinone) B18 subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285260.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXZ0
    Conserved Domains (1) summary
    pfam05676
    Location:38 → 100
    NDUF_B7; NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)

  2. NM_001298330.1 → NP_001285259.1  NADH dehydrogenase (ubiquinone) B18 subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285259.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXZ0
    Conserved Domains (1) summary
    pfam05676
    Location:38 → 100
    NDUF_B7; NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)

  3. NM_132765.2 → NP_572993.1  NADH dehydrogenase (ubiquinone) B18 subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572993.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXZ0
    Related
    FBpp0073777
    Conserved Domains (1) summary
    pfam05676
    Location:38 → 100
    NDUF_B7; NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXZ0 Q9VXZ0

Gene LinkOut

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