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Hap40 Huntingtin-associated protein 40 kDa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32507, updated on 4-Apr-2024

Summary

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Official Symbol
Hap40provided by FlyBase
Official Full Name
Huntingtin-associated protein 40 kDaprovided by FlyBase
Primary source
FLYBASE:FBgn0030671
Locus tag
Dmel_CG8134
See related
AllianceGenome:FB:FBgn0030671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg8134; CG8134; dhap40; Dmel\CG8134
Summary
Predicted to be involved in vesicle cytoskeletal trafficking. Predicted to be active in early endosome. Orthologous to human F8A3 (coagulation factor VIII associated 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
13E8-13E8; 1-51 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15704125..15705806)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15598158..15599839)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington's disease pathogenesis. Xu S, et al. PLoS Genet, 2022 Jul. PMID 35853002, Free PMC Article
  2. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
  3. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
  5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein stabilization IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in vesicle cytoskeletal trafficking IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Huntingtin-associated protein 40 kDa
Names
CG8134-PA
CG8134-PB
Hap40-PA
Hap40-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15704125..15705806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298354.1 → NP_001285283.1  Huntingtin-associated protein 40 kDa, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285283.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXR6

  2. NM_132828.2 → NP_573056.1  Huntingtin-associated protein 40 kDa, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573056.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXR6
    Related
    FBpp0073870
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXR6 Q9VXR6

Gene LinkOut

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