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CG4678 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32652, updated on 4-Apr-2024

Summary

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Official Symbol
CG4678provided by FlyBase
Primary source
FLYBASE:FBgn0030778
Locus tag
Dmel_CG4678
See related
AllianceGenome:FB:FBgn0030778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4678
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be active in extracellular space. Is expressed in adult head; embryonic/larval posterior spiracle; and gut section. Orthologous to human CPM (carboxypeptidase M). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
15A1-15A3; 1-55 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16696131..16711145)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16590164..16605178)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene singles bar Neighboring gene Abnormal X segregation Neighboring gene Septin 4 Neighboring gene uncharacterized protein Neighboring gene spheroide Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reduction in mutation frequency by very low-dose gamma irradiation of Drosophila melanogaster germ cells. Ogura K, et al. Radiat Res, 2009 Jan. PMID 19138046
  2. The genomic response to courtship song stimulation in female Drosophila melanogaster. Immonen E, et al. Proc Biol Sci, 2012 Apr 7. PMID 21976688, Free PMC Article
  3. X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila. Legube G, et al. Genes Dev, 2006 Apr 1. PMID 16547175, Free PMC Article
  4. The Insect Prothoracic Gland as a Model for Steroid Hormone Biosynthesis and Regulation. Ou Q, et al. Cell Rep, 2016 Jun 28. PMID 27320926, Free PMC Article
  5. Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization. Menoret D, et al. Genome Biol, 2013 Aug 23. PMID 23972280, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4678-PD
CG4678-PE
CG4678-PF
CG4678-PG
CG4678-PI
CG4678-PJ
CG4678-PK
CG4678-PL
NP_001033850.2
NP_001138210.1
  • unusual splice
NP_001138211.1
  • unusual splice
NP_001245718.1
NP_001285344.1
NP_001285345.1
NP_573152.2
  • unusual splice
NP_728012.2
  • unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16696131..16711145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144738.2 → NP_001138210.1  uncharacterized protein Dmel_CG4678, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138210.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0Z6, G4LU56, G4LU72
    Conserved Domains (2) summary
    cd03858
    Location:72 → 368
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    cd11308
    Location:372 → 446
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

  2. NM_001144739.2 → NP_001138211.1  uncharacterized protein Dmel_CG4678, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138211.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0Z5, G4LU56
    Conserved Domains (2) summary
    cd03858
    Location:72 → 377
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    cd11308
    Location:381 → 455
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

  3. NM_001298415.1 → NP_001285344.1  uncharacterized protein Dmel_CG4678, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285344.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4LU56, X2JFS7
    Conserved Domains (2) summary
    cd03858
    Location:72 → 373
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    cd11308
    Location:377 → 451
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

  4. NM_001038761.2 → NP_001033850.2  uncharacterized protein Dmel_CG4678, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033850.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A023GPN7, G4LU56
    Conserved Domains (2) summary
    cd03858
    Location:72 → 363
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    cd11308
    Location:367 → 441
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

  5. NM_001258789.2 → NP_001245718.1  uncharacterized protein Dmel_CG4678, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245718.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4LU56, M9NFA0
    Conserved Domains (2) summary
    cd03858
    Location:72 → 363
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    cd11308
    Location:367 → 441
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

  6. NM_001298416.1 → NP_001285345.1  uncharacterized protein Dmel_CG4678, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285345.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JC90
    Conserved Domains (2) summary
    cd03858
    Location:1 → 254
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    cd11308
    Location:258 → 332
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

  7. NM_167536.4 → NP_728012.2  uncharacterized protein Dmel_CG4678, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728012.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4N7, G4LU56
    Conserved Domains (2) summary
    cd03858
    Location:72 → 377
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    cd11308
    Location:381 → 455
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

  8. NM_132924.4 → NP_573152.2  uncharacterized protein Dmel_CG4678, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573152.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4LU56, Q9VXC4
    Conserved Domains (2) summary
    cd03858
    Location:72 → 368
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    cd11308
    Location:372 → 446
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A023GPN7 A0A023GPN7
A4V4N7 A4V4N7
B7Z0Z5 B7Z0Z5
B7Z0Z6 B7Z0Z6
M9NFA0 M9NFA0
Q8MRP2 Q8MRP2
Q9VXC4 Q9VXC4
X2JC90 X2JC90
X2JFS7 X2JFS7

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