U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CALM calmodulin-like [ Bos taurus (cattle) ]

Gene ID: 326597, updated on 22-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
CALM
Gene description
calmodulin-like
See related
BGD:BT17229
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CALM2
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 20
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (8144460..8145622)

Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene basic transcription factor 3 Neighboring gene uncharacterized LOC132343202 Neighboring gene forkhead box D1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Single-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics. He Y, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26311846, Free PMC Article
  2. Quantitative protein topography analysis and high-resolution structure prediction using hydroxyl radical labeling and tandem-ion mass spectrometry (MS). Kaur P, et al. Mol Cell Proteomics, 2015 Apr. PMID 25687570, Free PMC Article
  3. Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses. Kumrungsee T, et al. Biochim Biophys Acta, 2014 Oct. PMID 25092650
  4. Analysis of the oxidative damage-induced conformational changes of apo- and holocalmodulin by dose-dependent protein oxidative surface mapping. Sharp JS, et al. Biophys J, 2007 Mar 1. PMID 17158574, Free PMC Article
  5. Structure of Escherichia coli fragment TR2C from calmodulin to 1.7 A resolution. Olsson LL, et al. Acta Crystallogr D Biol Crystallogr, 2001 May. PMID 11320306

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Binding of Amyloid beta(1-42)-Calmodulin Complexes to Plasma Membrane Lipid Rafts in Cerebellar Granule Neurons Alters Resting Cytosolic Calcium Homeostasis.
    Title: Binding of Amyloid β(1-42)-Calmodulin Complexes to Plasma Membrane Lipid Rafts in Cerebellar Granule Neurons Alters Resting Cytosolic Calcium Homeostasis.
  2. We found that the major protein repeatedly identified as STRA6-associated protein is calmodulin, consistent with the cryogenic electron microscopy (cryo-EM) study of zebrafish STRA6 associated with calmodulin
    Title: Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport.
  3. These findings suggest that lysoPC induces CaM phosphorylation at Tyr(99) by a Src family kinase and that phosphorylated CaM activates PI3K to produce PIP3, which promotes TRPC6 translocation to the cell membrane.
    Title: Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation.
  4. calmodulin promotes catalysis by shaping the physical and temporal conformational behaviors of NOS.
    Title: Single-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics.
  5. examination of Ca(+2)-calmodulin showing highly significant correlations between surface area and side-chain contact predictions for individual side chains and the crystal structure, is reported.
    Title: Quantitative protein topography analysis and high-resolution structure prediction using hydroxyl radical labeling and tandem-ion mass spectrometry (MS).
  6. Fluorescence decays of fluorescently labeled CaM bound to eNOS reveal four distinct conformational states and single-molecule fluorescence trajectories show multiple fluorescence states with transitions between states
    Title: Fluorescence quenching studies of structure and dynamics in calmodulin-eNOS complexes.
  7. key regulatory role of CaM involves the stabilization of structural intermediates and precise positioning of the pivot for the FMN domain tethered shuttling motion to accommodate efficient and rapid electron transfer in the homodimer of eNOS.
    Title: Holoenzyme structures of endothelial nitric oxide synthase - an allosteric role for calmodulin in pivoting the FMN domain for electron transfer.
  8. The results provide a basic idea that could lead to the development of small peptides binding with high affinity to CaM and inhibiting Ca(2)-CaM complex formation in the future.
    Title: Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses.
  9. CaM is collapsed around the adenylyl cyclase 8 peptides that binds to CaM in an antiparallel orientation.
    Title: Structural insights into calmodulin/adenylyl cyclase 8 interaction.
  10. Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a.
    Title: Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of ryanodine-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
calmodulin
Names
caM
calmodulin 2 (phosphorylase kinase, delta)
NP_001159980.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166508.3 → NP_001159980.2  calmodulin

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000020
    UniProtKB/TrEMBL
    F1MLH6
    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    8144460..8145622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.