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RAB37 RAB37, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 326624, updated on 3-Apr-2024

Summary

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Official Symbol
RAB37provided by HGNC
Official Full Name
RAB37, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:30268
See related
Ensembl:ENSG00000172794 MIM:609956; AllianceGenome:HGNC:30268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]
Expression
Broad expression in spleen (RPKM 9.4), bone marrow (RPKM 7.1) and 20 other tissues See more
Orthologs
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Genomic context

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See RAB37 in Genome Data Viewer
Location:
17q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74671131..74747335)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75561860..75639214)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72667270..72743474)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CD300LD antisense RNA 1 Neighboring gene CD300 molecule like family member d Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12713 Neighboring gene uncharacterized LOC101928343 Neighboring gene CD300e molecule Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:72627822-72628322 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:72628323-72628823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12714 Neighboring gene uncharacterized LOC105371894 Neighboring gene CD300 molecule like family member f Neighboring gene uncharacterized LOC124904057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72733027-72733750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72734475-72735197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12717 Neighboring gene SLC9A3R1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72743321-72743916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8939 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72745205-72745830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72747322-72747863 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72753485-72754231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72754232-72754979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72754980-72755726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72755727-72756474 Neighboring gene microRNA 3615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72759127-72759878 Neighboring gene NHERF family PDZ scaffold protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12718 Neighboring gene N-acetyltransferase 9 (putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37. Xin L, et al. Cell Cycle, 2020 Oct. PMID 32926650, Free PMC Article
  2. RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma. Li Y, et al. Clin Cancer Res, 2018 Dec 15. PMID 30131385
  3. The GTPase Rab37 Participates in the Control of Insulin Exocytosis. Ljubicic S, et al. PLoS One, 2013. PMID 23826383, Free PMC Article
  4. An association study on genetic polymorphisms of Rab37 gene with the risk of esophageal squamous cell carcinoma in a Chinese Han population. Xu X, et al. Int J Med Sci, 2013. PMID 23372429, Free PMC Article
  5. Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer. Wu CY, et al. Lung Cancer, 2009 Mar. PMID 18687502

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.
    Title: Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.
  2. Low RAB37 expression is associated with lung cancer.
    Title: Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.
  3. This study shows that RAB37 hypermethylation is involved in NPC metastasis and chemoresistance, and that our prognostic model can identify patients who are at a high risk of distant metastasis and might benefit from for docetaxel IC.
    Title: RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.
  4. Rab37-mediated SFRP1 secretion suppresses cancer stemness.
    Title: Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.
  5. Findings indicate that patients with low vesicle associated membrane protein 8 (VAMP8)/low rab GTP-binding protein RAB37 (RAB37) expression profile showed significantly high risk of death even after adjusting for tumor metastasis parameter.
    Title: VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.
  6. results demonstrate a role of RAB37 in autophagosome formation through a molecular connection of RAB37, ATG5-12, ATG16L1 up to LC3B, suggesting an organiser role of RAB37 during autophagosomal membrane biogenesis.
    Title: RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly.
  7. Our findings suggest that Rab37-mediated TSP1 secretion in cancer cells suppresses metastasis and angiogenesis via a cross-talk with endothelial cells and reveal a novel component of the vesicular exocytic machinery in tumor microenvironment and tumor progression
    Title: Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
  8. Results identify Rab37 as an additional component of the machinery governing exocytosis of beta-cells and suggest that impaired expression of this GTPase may contribute to defective insulin release in pre-diabetic and diabetic conditions.
    Title: The GTPase Rab37 Participates in the Control of Insulin Exocytosis.
  9. RAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 migration axis in vitro and in vivo and to suppress tumor metastasis.
    Title: Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
  10. Rab37 mRNA was specifically expressed in some ESCC cell lines but its genetic polymorphisms were not associated with esophageal squamous cell carcinoma.
    Title: An association study on genetic polymorphisms of Rab37 gene with the risk of esophageal squamous cell carcinoma in a Chinese Han population.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
EBI GWAS Catalog
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of RAB37, member RAS oncogene family by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ30284, FLJ32507

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ras-related protein Rab-37
Names
RAB37, member of RAS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006638.3 → NP_001006639.1  ras-related protein Rab-37 isoform 2

    See identical proteins and their annotated locations for NP_001006639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, 5' UTR, and alternate start codon, and includes an alternate coding exon, compared to variant 3. The resulting isoform (2) has a distinct and longer N-terminus, compared to isoform 3.
    Source sequence(s)
    AC016888, AK098068, BC016615
    Consensus CDS
    CCDS32722.1
    UniProtKB/Swiss-Prot
    A8MXF5, A8MYT0, Q8IWA7, Q96AX2
    UniProtKB/TrEMBL
    A8MTC6
    Related
    ENSP00000376389.5, ENST00000392613.10
    Conserved Domains (1) summary
    cd04112
    Location:31 → 220
    Rab26; Rab GTPase family 26 (Rab26)

  2. NM_001163989.3 → NP_001157461.2  ras-related protein Rab-37 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter, 5' UTR, and alternate start codon, and includes an alternate coding exon, compared to variant 3. The resulting isoform (4) has a distinct and longer N-terminus, compared to isoform 3.
    Source sequence(s)
    AC016888
    Consensus CDS
    CCDS54161.1
    UniProtKB/TrEMBL
    A0A9H3ZVF6
    Related
    ENSP00000376390.5, ENST00000392614.8

  3. NM_001163990.2 → NP_001157462.1  ras-related protein Rab-37 isoform 5

    See identical proteins and their annotated locations for NP_001157462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter, 5' UTR and alternate start codon, compared to variant 3. The resulting isoform (5) has a distinct and shorter N-terminus, compared to isoform 3.
    Source sequence(s)
    AC016888, AK296172, BC016615
    Consensus CDS
    CCDS54162.1
    UniProtKB/TrEMBL
    A8MTC6
    Related
    ENSP00000376388.3, ENST00000392612.7
    Conserved Domains (1) summary
    cd04112
    Location:30 → 183
    Rab26; Rab GTPase family 26 (Rab26)

  4. NM_001330471.2 → NP_001317400.1  ras-related protein Rab-37 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016888, AK057069, AK098068, AK296062, BC016615
    Consensus CDS
    CCDS82198.1
    UniProtKB/TrEMBL
    A8MTC6, B7Z3L0
    Related
    ENSP00000432086.1, ENST00000528438.5

  5. NM_175738.5 → NP_783865.1  ras-related protein Rab-37 isoform 3

    See identical proteins and their annotated locations for NP_783865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes isoform 3.
    Source sequence(s)
    AC016888, AK290202, BC016615, DA164538
    Consensus CDS
    CCDS11703.1
    UniProtKB/TrEMBL
    A8MSP2
    Related
    ENSP00000383934.4, ENST00000402449.8
    Conserved Domains (2) summary
    smart00175
    Location:24 → 185
    RAB; Rab subfamily of small GTPases
    cd04112
    Location:23 → 213
    Rab26; Rab GTPase family 26 (Rab26)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74671131..74747335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75561860..75639214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006637.1: Suppressed sequence

    Description
    NM_001006637.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96AX2.3 GenPept UniProtKB/Swiss-Prot:Q96AX2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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