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Slc39a9 solute carrier family 39 (zinc transporter), member 9 [ Mus musculus (house mouse) ]

Gene ID: 328133, updated on 23-Apr-2024

Summary

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Official Symbol
Slc39a9provided by MGI
Official Full Name
solute carrier family 39 (zinc transporter), member 9provided by MGI
Primary source
MGI:MGI:1914820
See related
Ensembl:ENSMUSG00000048833 AllianceGenome:MGI:1914820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zip9; 2010002A02Rik; 2610511I23Rik; 4833420E20Rik
Summary
Predicted to enable metal ion transmembrane transporter activity. Predicted to be involved in metal ion transport and transmembrane transport. Predicted to act upstream of or within zinc ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SLC39A9 (solute carrier family 39 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 22.7), colon adult (RPKM 21.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C3; 12 36.91 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80690657..80730116)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80643883..80683342)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32644 Neighboring gene predicted gene, 23817 Neighboring gene STARR-positive B cell enhancer ABC_E4032 Neighboring gene ERH mRNA splicing and mitosis factor Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1, opposite strand Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 Neighboring gene predicted gene, 51986

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice. Song L, et al. Front Endocrinol (Lausanne), 2023. PMID 37305050, Free PMC Article
  2. Non-classical testosterone signaling in spermatogenic GC-2 cells is mediated through ZIP9 interacting with Gnα11. Shihan M, et al. Cell Signal, 2015 Oct. PMID 26208885
  3. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice.
    Title: ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice.
  2. ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells.
    Title: Non-classical testosterone signaling in spermatogenic GC-2 cells is mediated through ZIP9 interacting with Gnα11.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables androgen binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cellular response to testosterone stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc transporter ZIP9
Names
ZIP-9
solute carrier family 39 member 9
zrt- and Irt-like protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026244.2 → NP_080520.2  zinc transporter ZIP9

    See identical proteins and their annotated locations for NP_080520.2

    Status: VALIDATED

    Source sequence(s)
    BC058649, BC072655, BY148507, CO040789
    Consensus CDS
    CCDS49099.1
    UniProtKB/Swiss-Prot
    B2RY14, Q8BFU1
    UniProtKB/TrEMBL
    A0A1W2P6Y1
    Related
    ENSMUSP00000082343.6, ENSMUST00000085245.7
    Conserved Domains (1) summary
    pfam02535
    Location:9 → 302
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    80690657..80730116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516033.4 → XP_006516096.1  zinc transporter ZIP9 isoform X3

    Conserved Domains (1) summary
    cl00437
    Location:9 → 144
    Zip; ZIP Zinc transporter

  2. XM_017315121.3 → XP_017170610.1  zinc transporter ZIP9 isoform X1

    UniProtKB/Swiss-Prot
    B2RY14, Q8BFU1
    UniProtKB/TrEMBL
    A0A1W2P6Y1
    Conserved Domains (1) summary
    pfam02535
    Location:9 → 302
    Zip; ZIP Zinc transporter

  3. XM_006516032.4 → XP_006516095.1  zinc transporter ZIP9 isoform X2

    Conserved Domains (1) summary
    cl00437
    Location:56 → 226
    Zip; ZIP Zinc transporter

  4. XM_006516034.5 → XP_006516097.1  zinc transporter ZIP9 isoform X4

    Conserved Domains (1) summary
    pfam02535
    Location:9 → 278
    Zip; ZIP Zinc transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFU1.1 GenPept UniProtKB/Swiss-Prot:Q8BFU1

Gene LinkOut

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