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Zfp236 zinc finger protein 236 [ Mus musculus (house mouse) ]

Gene ID: 329002, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp236provided by MGI
Official Full Name
zinc finger protein 236provided by MGI
Primary source
MGI:MGI:1926950
See related
Ensembl:ENSMUSG00000041258 AllianceGenome:MGI:1926950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm335
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF236 (zinc finger protein 236). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 8.4), ovary adult (RPKM 4.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E3; 18 56.26 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (82611718..82711044, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (82593593..82692915, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene myelin basic protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:82698694-82698847 Neighboring gene STARR-positive B cell enhancer ABC_E7619 Neighboring gene ribosomal protein L21, pseudogene 8 Neighboring gene STARR-seq mESC enhancer starr_45208 Neighboring gene predicted gene, 57823 Neighboring gene STARR-seq mESC enhancer starr_45213 Neighboring gene predicted gene 10524 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:82886249-82886432 Neighboring gene predicted gene, 50351 Neighboring gene microRNA 5112 Neighboring gene RIKEN cDNA 2210420H20 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identifying key m(6)A-methylated lncRNAs and genes associated with neural tube defects via integrative MeRIP and RNA sequencing analyses. Yang J, et al. Front Genet, 2022. PMID 36482889, Free PMC Article
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 236

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374229.1 → NP_001361158.1  zinc finger protein 236 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC119259, AC158975
    Consensus CDS
    CCDS89291.1
    UniProtKB/TrEMBL
    S4R299
    Related
    ENSMUSP00000138557.2, ENSMUST00000182122.8
    Conserved Domains (5) summary
    COG5048
    Location:653 → 1058
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1256 → 1276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:1374 → 1675
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13465
    Location:1740 → 1764
    zf-H2C2_2; Zinc-finger double domain

  2. NM_177832.4 → NP_808500.2  zinc finger protein 236 isoform 2

    See identical proteins and their annotated locations for NP_808500.2

    Status: VALIDATED

    Source sequence(s)
    AC119259, AC158975
    Consensus CDS
    CCDS50337.1
    UniProtKB/TrEMBL
    B2RR24
    Related
    ENSMUSP00000130004.2, ENSMUST00000171071.9
    Conserved Domains (5) summary
    COG5048
    Location:605 → 1010
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1208 → 1228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:1326 → 1627
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13465
    Location:1692 → 1716
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    82611718..82711044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526494.5 → XP_006526557.1  zinc finger protein 236 isoform X3

    Conserved Domains (5) summary
    COG5048
    Location:653 → 1058
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1256 → 1276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:1374 → 1569
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13465
    Location:1696 → 1720
    zf-H2C2_2; Zinc-finger double domain

  2. XM_036161185.1 → XP_036017078.1  zinc finger protein 236 isoform X4

    Conserved Domains (6) summary
    COG5048
    Location:596 → 1001
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:144 → 164
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1199 → 1219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:1317 → 1618
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13465
    Location:1127 → 1151
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:1605 → 1653
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  3. XM_006526493.4 → XP_006526556.1  zinc finger protein 236 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:637 → 1042
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:185 → 205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1240 → 1260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:1358 → 1659
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13465
    Location:1724 → 1748
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006526492.5 → XP_006526555.1  zinc finger protein 236 isoform X1

    See identical proteins and their annotated locations for XP_006526555.1

    Conserved Domains (5) summary
    COG5048
    Location:646 → 1051
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1249 → 1269
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:1367 → 1668
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13465
    Location:1177 → 1201
    zf-H2C2_2; Zinc-finger double domain

  5. XM_017317934.3 → XP_017173423.1  zinc finger protein 236 isoform X6

    Conserved Domains (6) summary
    COG5048
    Location:212 → 617
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:731 → 751
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:815 → 835
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:933 → 1234
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00096
    Location:43 → 65
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1299 → 1323
    zf-H2C2_2; Zinc-finger double domain

  6. XM_017317933.3 → XP_017173422.1  zinc finger protein 236 isoform X4

    Conserved Domains (6) summary
    COG5048
    Location:596 → 1001
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:144 → 164
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1199 → 1219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:1317 → 1618
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13465
    Location:1127 → 1151
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:1605 → 1653
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  7. XM_011247084.4 → XP_011245386.1  zinc finger protein 236 isoform X1

    See identical proteins and their annotated locations for XP_011245386.1

    Conserved Domains (5) summary
    COG5048
    Location:646 → 1051
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1249 → 1269
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:1367 → 1668
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13465
    Location:1177 → 1201
    zf-H2C2_2; Zinc-finger double domain

  8. XM_011247083.3 → XP_011245385.1  zinc finger protein 236 isoform X1

    See identical proteins and their annotated locations for XP_011245385.1

    Conserved Domains (5) summary
    COG5048
    Location:646 → 1051
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1249 → 1269
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:1367 → 1668
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13465
    Location:1177 → 1201
    zf-H2C2_2; Zinc-finger double domain

  9. XM_006526497.5 → XP_006526560.1  zinc finger protein 236 isoform X5

    See identical proteins and their annotated locations for XP_006526560.1

    Conserved Domains (5) summary
    COG5048
    Location:653 → 1058
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1256 → 1276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1184 → 1208
    zf-H2C2_2; Zinc-finger double domain
    NF033208
    Location:1348 → 1533
    choice_anch_E; choice-of-anchor E domain-containing protein

RNA

  1. XR_003952527.2 RNA Sequence

  2. XR_003952528.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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