COX6B Cytochrome c oxidase subunit 6B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: COX6Bprovided by FlyBase
Official Full Name: Cytochrome c oxidase subunit 6Bprovided by FlyBase
Primary source: FLYBASE:FBgn0031066
Locus tag: Dmel_CG14235
See related: AllianceGenome:FB:FBgn0031066
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CcoVIb; CG14235; CoVIb; Cox6b; COXG; Dmel\CG14235; Q8IQW2; vib; VIb
Summary: Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to several human genes including COX6B1 (cytochrome c oxidase subunit 6B1). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 18E5-18E5; 1-64 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19740537..19744335, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19634570..19638368, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of mitochondrial respiratory chain complex IV	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex IV	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: cytochrome c oxidase subunit 6B

Names: CG14235-PA; CG14235-PB; CG14235-PC; CG14235-PD; COX6B-PA; COX6B-PB; COX6B-PC; COX6B-PD; cytochrome c oxidase VIb; cytochrome c oxidase polypeptide VIb; cytochrome c oxidase subunit VIb; cytochrome c oxidase subunitVIb; subunit VIb

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19740537..19744335 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167680.3 → NP_728296.1 cytochrome c oxidase subunit 6B, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728296.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IQW2

Related

FBpp0074585

Conserved Domains (1) summary

cd00926
Location:3 → 76

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_167678.3 → NP_728294.1 cytochrome c oxidase subunit 6B, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728294.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VWD1

Related

FBpp0074584

Conserved Domains (1) summary

cd00926
Location:22 → 95

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_001258838.2 → NP_001245767.1 cytochrome c oxidase subunit 6B, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245767.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IQW2

Conserved Domains (1) summary

cd00926
Location:3 → 76

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_167679.3 → NP_728295.1 cytochrome c oxidase subunit 6B, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728295.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IQW2

Related

FBpp0074586

Conserved Domains (1) summary

cd00926
Location:3 → 76

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...