Format

Send to:

Choose Destination

Nek5 NIMA (never in mitosis gene a)-related expressed kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 330721, updated on 5-Sep-2021

Summary

Official Symbol
Nek5provided by MGI
Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 5provided by MGI
Primary source
MGI:MGI:2142824
See related
Ensembl:ENSMUSG00000037738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BB049667; 6530411J22
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nek5 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22563631..22615443, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22073615..22125418, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23184088..23235525, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ATPase, Cu++ transporting, beta polypeptide Neighboring gene asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase) Neighboring gene small nucleolar RNA U13 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 3 Neighboring gene cytoskeleton associated protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Nek5
Names
never in mitosis A-related kinase 5
nimA-related protein kinase 5
NP_001334247.1
NP_808566.2
XP_006509217.1
XP_006509218.1
XP_006509222.1
XP_011240445.1
XP_011240446.1
XP_011240447.1
XP_011240448.1
XP_011240449.1
XP_011240451.1
XP_017168352.1
XP_030099482.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347318.2NP_001334247.1  serine/threonine-protein kinase Nek5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) has a distinct and longer C-terminus, compared to isoform 1.
    Source sequence(s)
    AK032672, AK054168, BC053516
    Consensus CDS
    CCDS85511.1
    UniProtKB/Swiss-Prot
    Q7TSC3
    Related
    ENSMUSP00000148211.2, ENSMUST00000209656.2
  2. NM_177898.5NP_808566.2  serine/threonine-protein kinase Nek5 isoform 1

    See identical proteins and their annotated locations for NP_808566.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AK032672, AK054168
    Consensus CDS
    CCDS52518.1
    UniProtKB/Swiss-Prot
    Q7TSC3
    Related
    ENSMUSP00000126705.2, ENSMUST00000169834.2
    Conserved Domains (2) summary
    cd08225
    Location:3255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    smart00220
    Location:4255
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22563631..22615443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242145.3XP_011240447.1  serine/threonine-protein kinase Nek5 isoform X6

    Conserved Domains (1) summary
    cd08225
    Location:3255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
  2. XM_006509155.5XP_006509218.1  serine/threonine-protein kinase Nek5 isoform X3

    Conserved Domains (1) summary
    cd08225
    Location:3255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
  3. XM_030243622.2XP_030099482.1  serine/threonine-protein kinase Nek5 isoform X4

    Conserved Domains (1) summary
    cd08225
    Location:3255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
  4. XM_011242144.3XP_011240446.1  serine/threonine-protein kinase Nek5 isoform X5

    Conserved Domains (1) summary
    cd08225
    Location:3255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
  5. XM_011242146.4XP_011240448.1  serine/threonine-protein kinase Nek5 isoform X9

    Conserved Domains (1) summary
    cd08225
    Location:3255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
  6. XM_011242149.4XP_011240451.1  serine/threonine-protein kinase Nek5 isoform X11

  7. XM_006509154.4XP_006509217.1  serine/threonine-protein kinase Nek5 isoform X1

    Conserved Domains (1) summary
    cd08225
    Location:3255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
  8. XM_011242143.3XP_011240445.1  serine/threonine-protein kinase Nek5 isoform X2

    Conserved Domains (1) summary
    cd08225
    Location:3255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
  9. XM_017312863.3XP_017168352.1  serine/threonine-protein kinase Nek5 isoform X7

    Conserved Domains (1) summary
    cd08225
    Location:3255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
  10. XM_006509159.5XP_006509222.1  serine/threonine-protein kinase Nek5 isoform X8

    Conserved Domains (1) summary
    cd08225
    Location:3255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
  11. XM_011242147.3XP_011240449.1  serine/threonine-protein kinase Nek5 isoform X10

    Conserved Domains (1) summary
    cd08225
    Location:3255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

RNA

  1. XR_003947310.2 RNA Sequence

  2. XR_004934846.1 RNA Sequence

Support Center