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Slc7a6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 [ Mus musculus (house mouse) ]

Gene ID: 330836, updated on 11-Apr-2024

Summary

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Official Symbol
Slc7a6provided by MGI
Official Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 6provided by MGI
Primary source
MGI:MGI:2142598
See related
Ensembl:ENSMUSG00000031904 AllianceGenome:MGI:2142598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LAT3; LAT-2; y+LAT-2
Summary
Predicted to enable L-amino acid transmembrane transporter activity and basic amino acid transmembrane transporter activity. Predicted to be involved in basic amino acid transmembrane transport and ornithine transport. Predicted to act upstream of or within amino acid transport. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Is expressed in brain; embryo; and gonad. Orthologous to human SLC7A6 (solute carrier family 7 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 13.4), whole brain E14.5 (RPKM 13.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Slc7a6 in Genome Data Viewer
Location:
8 D3; 8 53.1 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106894718..106925346)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106168219..106198714)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810019D21 gene Neighboring gene STARR-positive B cell enhancer ABC_E9739 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr8:108674075-108674376 Neighboring gene phospholipase A2, group XV Neighboring gene solute carrier family 7, member 6 opposite strand Neighboring gene protein arginine N-methyltransferase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2. Hinz KM, et al. Mol Endocrinol, 2015 Jun. PMID 25945809, Free PMC Article
  2. Uptake of betaine into mouse cumulus-oocyte complexes via the SLC7A6 isoform of y+L transporter. Corbett HE, et al. Biol Reprod, 2014 Apr. PMID 24599290
  3. Amino acid transporter LAT3 is required for podocyte development and function. Sekine Y, et al. J Am Soc Nephrol, 2009 Jul. PMID 19443642, Free PMC Article
  4. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
  5. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these data help to elucidate the molecular mechanisms and role of Lat2 in thyroid hormone transport.
    Title: Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2.
  2. Both transcripts and protein of one y+L isoform, SLC7A6 (y+LAT2), are present in cumulus oocyte complexes, with little or no expression in isolated germinal vesicle (GV)-stage oocytes, MII eggs, or one-cell embryos.
    Title: Uptake of betaine into mouse cumulus-oocyte complexes via the SLC7A6 isoform of y+L transporter.
  3. LAT3 may play a crucial role in the development and maintenance of podocyte structure and function by regulating protein synthesis and the actin cytoskeleton.
    Title: Amino acid transporter LAT3 is required for podocyte development and function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-arginine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-lysine:L-arginine antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables arginine binding ISO
Inferred from Sequence Orthology
more info
  
enables basic amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-leucine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine betaine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ornithine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Y+L amino acid transporter 2
Names
solute carriersolute carrier family 7 (cationic amino acid transporter, y+ system), member 6
y(+)L-type amino acid transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357381.1 → NP_001344310.1  Y+L amino acid transporter 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC133195
    Consensus CDS
    CCDS22631.1
    UniProtKB/Swiss-Prot
    Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

  2. NM_001357382.1 → NP_001344311.1  Y+L amino acid transporter 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI118666, AK030762, BB398929, BB855052, CF725752
    Conserved Domains (1) summary
    cl26159
    Location:1 → 293
    AA_permease_2; Amino acid permease

  3. NM_178798.4 → NP_848913.1  Y+L amino acid transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_848913.1

    Status: VALIDATED

    Source sequence(s)
    AI118666, AK053899, BB398929, BB855052, CF725752
    Consensus CDS
    CCDS22631.1
    UniProtKB/Swiss-Prot
    Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
    Related
    ENSMUSP00000034378.4, ENSMUST00000034378.5
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

RNA

  1. NR_151676.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC133195, AI118666, AK046548, AK049478, BB398929, BB855052, CF725752

  2. NR_151677.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC133195

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106894718..106925346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154138.1 → XP_036010031.1  Y+L amino acid transporter 2 isoform X3

    UniProtKB/Swiss-Prot
    Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

  2. XM_006531138.5 → XP_006531201.1  Y+L amino acid transporter 2 isoform X3

    See identical proteins and their annotated locations for XP_006531201.1

    UniProtKB/Swiss-Prot
    Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

  3. XM_006531136.4 → XP_006531199.1  Y+L amino acid transporter 2 isoform X2

    Conserved Domains (1) summary
    TIGR00911
    Location:30 → 514
    2A0308; L-type amino acid transporter

  4. XM_030243635.2 → XP_030099495.1  Y+L amino acid transporter 2 isoform X3

    UniProtKB/Swiss-Prot
    Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

  5. XM_017312868.3 → XP_017168357.1  Y+L amino acid transporter 2 isoform X3

    UniProtKB/Swiss-Prot
    Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

  6. XM_030243634.2 → XP_030099494.1  Y+L amino acid transporter 2 isoform X3

    UniProtKB/Swiss-Prot
    Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

  7. XM_006531135.5 → XP_006531198.1  Y+L amino acid transporter 2 isoform X1

    Conserved Domains (1) summary
    TIGR00911
    Location:34 → 518
    2A0308; L-type amino acid transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGK6.1 GenPept UniProtKB/Swiss-Prot:Q8BGK6

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