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Arhgap32 Rho GTPase activating protein 32 [ Mus musculus (house mouse) ]

Gene ID: 330914, updated on 16-Oct-2021

Summary

Official Symbol
Arhgap32provided by MGI
Official Full Name
Rho GTPase activating protein 32provided by MGI
Primary source
MGI:MGI:2450166
See related
Ensembl:ENSMUSG00000041444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grit; Rics; Gc-gap; Px-rics; p250Gap; mKIAA0712; p200Rhogap; 3426406O18Rik
Expression
Broad expression in cortex adult (RPKM 9.5), frontal lobe adult (RPKM 9.3) and 22 other tissues See more
Orthologs
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Genomic context

See Arhgap32 in Genome Data Viewer
Location:
9; 9 A4
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (31927921..32176061)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (32016625..32268443)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (31923721..32072084)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene triosephosphate isomerase related sequence 4 Neighboring gene predicted gene, 47465 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 5 Neighboring gene predicted gene, 39317

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0712

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in fibrillar center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 32
Names
GAB-associated Cdc42/Rac GTPase-activating protein
GTPase-activating protein for Cdc42 and Rac1
Rho GTPase activating protein 33 pseudogene
brain-specific Rho GTPase-activating protein
rac GTPase activating protein
rho-type GTPase-activating protein 32
rho/Cdc42/Rac GTPase-activating protein RICS
rhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195632.2NP_001182561.1  rho GTPase-activating protein 32 isoform 1

    See identical proteins and their annotated locations for NP_001182561.1

    Status: VALIDATED

    Source sequence(s)
    AC132114, AC134607
    Consensus CDS
    CCDS57666.1
    UniProtKB/Swiss-Prot
    Q811P8
    Related
    ENSMUSP00000133898.2, ENSMUST00000174641.8
    Conserved Domains (3) summary
    cd07298
    Location:127241
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:263316
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:368562
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
  2. NM_001370957.1NP_001357886.1  rho GTPase-activating protein 32 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC132114, AC134607, AC160635
    Conserved Domains (4) summary
    cd07298
    Location:87201
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:223276
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    PHA03247
    Location:11971579
    PHA03247; large tegument protein UL36; Provisional
    cd04384
    Location:328522
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
  3. NM_001370958.1NP_001357887.1  rho GTPase-activating protein 32 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132114, AC134607, AC160635
    Conserved Domains (4) summary
    cd07298
    Location:101215
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:237290
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    PHA03247
    Location:12111593
    PHA03247; large tegument protein UL36; Provisional
    cd04384
    Location:342536
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
  4. NM_177379.5NP_796353.3  rho GTPase-activating protein 32 isoform 2

    See identical proteins and their annotated locations for NP_796353.3

    Status: VALIDATED

    Source sequence(s)
    AC132114, AC134607
    Consensus CDS
    CCDS22951.3
    UniProtKB/Swiss-Prot
    Q811P8
    Related
    ENSMUSP00000128448.3, ENSMUST00000168954.9
    Conserved Domains (1) summary
    cd04384
    Location:19213
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    31927921..32176061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510445.5XP_006510508.1  rho GTPase-activating protein 32 isoform X3

    See identical proteins and their annotated locations for XP_006510508.1

    Conserved Domains (4) summary
    cd07298
    Location:101215
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:237290
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    PHA03247
    Location:12111593
    PHA03247; large tegument protein UL36; Provisional
    cd04384
    Location:342536
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
  2. XM_030244425.2XP_030100285.1  rho GTPase-activating protein 32 isoform X4

    Conserved Domains (4) summary
    cd07298
    Location:87201
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:223276
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    PHA03247
    Location:11971579
    PHA03247; large tegument protein UL36; Provisional
    cd04384
    Location:328522
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
  3. XM_036155080.1XP_036010973.1  rho GTPase-activating protein 32 isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:9121294
    PHA03247; large tegument protein UL36; Provisional
    cd04384
    Location:43237
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
  4. XM_030244426.2XP_030100286.1  rho GTPase-activating protein 32 isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:9121294
    PHA03247; large tegument protein UL36; Provisional
    cd04384
    Location:43237
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
  5. XM_036155079.1XP_036010972.1  rho GTPase-activating protein 32 isoform X2

    Conserved Domains (4) summary
    cd07298
    Location:129243
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:265318
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    PHA03247
    Location:12391621
    PHA03247; large tegument protein UL36; Provisional
    cd04384
    Location:370564
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
  6. XM_006510442.4XP_006510505.1  rho GTPase-activating protein 32 isoform X1

    Conserved Domains (4) summary
    cd07298
    Location:141255
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:277330
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    PHA03247
    Location:12511633
    PHA03247; large tegument protein UL36; Provisional
    cd04384
    Location:382576
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_020962.1: Suppressed sequence

    Description
    NG_020962.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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