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Gsdmc2 gasdermin C2 [ Mus musculus (house mouse) ]

Gene ID: 331063, updated on 8-Feb-2024

Summary

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Official Symbol
Gsdmc2provided by MGI
Official Full Name
gasdermin C2provided by MGI
Primary source
MGI:MGI:2146102
See related
Ensembl:ENSMUSG00000056293 AllianceGenome:MGI:2146102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130023H10
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Acts upstream of or within intestinal epithelial cell development. Predicted to be located in cytoplasm. Is expressed in gut and urinary system. Orthologous to human GSDMC (gasdermin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 227.0), colon adult (RPKM 40.2) and 1 other tissue See more
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Genomic context

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Location:
15 D1; 15 27.91 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (63696177..63717042, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (63824328..63845193, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin C Neighboring gene gasdermin pseudogene Neighboring gene gasdermin C-like 1 Neighboring gene gasdermin C3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Tamura M, et al. Genomics, 2007 May. PMID 17350798
  2. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC130607

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables wide pore channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables wide pore channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intestinal epithelial cell development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in pyroptosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyroptosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in type 2 immune response IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gasdermin-C2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168274.1 → NP_001161746.1  gasdermin-C2

    See identical proteins and their annotated locations for NP_001161746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC140673, AK033603
    Consensus CDS
    CCDS37087.1
    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Related
    ENSMUSP00000140487.2, ENSMUST00000188691.2
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  2. NM_177912.4 → NP_808580.2  gasdermin-C2

    See identical proteins and their annotated locations for NP_808580.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC140673, AK033603
    Consensus CDS
    CCDS37087.1
    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Related
    ENSMUSP00000141066.2, ENSMUST00000188404.7
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    63696177..63717042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521097.4 → XP_006521160.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_006521160.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  2. XM_011245674.3 → XP_011243976.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_011243976.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  3. XM_011245670.3 → XP_011243972.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_011243972.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  4. XM_011245667.3 → XP_011243969.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_011243969.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  5. XM_011245676.3 → XP_011243978.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_011243978.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  6. XM_011245673.3 → XP_011243975.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_011243975.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  7. XM_011245668.3 → XP_011243970.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_011243970.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  8. XM_006521098.4 → XP_006521161.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_006521161.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  9. XM_011245677.3 → XP_011243979.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_011243979.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  10. XM_011245672.3 → XP_011243974.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_011243974.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  11. XM_011245671.3 → XP_011243973.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_011243973.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  12. XM_011245675.3 → XP_011243977.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_011243977.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  13. XM_011245669.3 → XP_011243971.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_011243971.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  14. XM_006521096.4 → XP_006521159.1  gasdermin-C2 isoform X1

    See identical proteins and their annotated locations for XP_006521159.1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  15. XM_030248612.1 → XP_030104472.1  gasdermin-C2 isoform X1

    UniProtKB/Swiss-Prot
    Q2KHK6, Q2KHK8, Q8CC94
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KHK6.2 GenPept UniProtKB/Swiss-Prot:Q2KHK6

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