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Dus1 Dihydrouridine synthase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33190, updated on 10-May-2024

Summary

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Official Symbol
Dus1provided by FlyBase
Official Full Name
Dihydrouridine synthase 1provided by FlyBase
Primary source
FLYBASE:FBgn0031238
Locus tag
Dmel_CG3645
See related
AllianceGenome:FB:FBgn0031238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3645; Dmel\CG3645
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA processing. Is expressed in organism. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Dus1 in Genome Data Viewer
Location:
21B5-21B7; 2-0.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (252589..271744, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (252589..271744, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene kismet Neighboring gene long non-coding RNA:CR44218 Neighboring gene RNaseP protein p30 Neighboring gene long non-coding RNA:CR44219 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mushroom body miniature

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular evolution of dihydrouridine synthases. Kasprzak JM, et al. BMC Bioinformatics, 2012 Jun 28. PMID 22741570, Free PMC Article
  2. Identification of mushroom body miniature, a zinc-finger protein implicated in brain development of Drosophila. Raabe T, et al. Proc Natl Acad Sci U S A, 2004 Sep 28. PMID 15375215, Free PMC Article
  3. Drosophila mini-white model system: new insights into positive position effects and the role of transcriptional terminators and gypsy insulator in transgene shielding. Silicheva M, et al. Nucleic Acids Res, 2010 Jan. PMID 19854952, Free PMC Article
  4. Phenotypes Associated with Second Chromosome P Element Insertions in Drosophila melanogaster. Kahsai L, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317776, Free PMC Article
  5. Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila. Meltzer H, et al. Nat Commun, 2019 May 8. PMID 31068592, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-dihydrouridine16 synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA-dihydrouridine17 synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dihydrouridine synthase 1
Names
CG3645-PA
CG3645-PB
CG3645-PC
Dus1-PA
Dus1-PB
Dus1-PC
NP_001259809.1
NP_608507.1
NP_722619.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    252589..271744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134663.4 → NP_608507.1  dihydrouridine synthase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608507.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960P2, Q9VPM1
    Related
    FBpp0077799
    Conserved Domains (3) summary
    TIGR01623
    Location:426 → 460
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:29 → 259
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:31 → 303
    Dus; Dihydrouridine synthase (Dus)

  2. NM_164377.3 → NP_722619.1  dihydrouridine synthase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722619.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960P2, Q9VPM1
    Related
    FBpp0077800
    Conserved Domains (3) summary
    TIGR01623
    Location:426 → 460
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:29 → 259
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:31 → 303
    Dus; Dihydrouridine synthase (Dus)

  3. NM_001272880.1 → NP_001259809.1  dihydrouridine synthase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259809.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960P2, Q9VPM1
    Conserved Domains (3) summary
    TIGR01623
    Location:426 → 460
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:29 → 259
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:31 → 303
    Dus; Dihydrouridine synthase (Dus)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPM1 Q9VPM1

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