U2af38 U2 small nuclear riboprotein auxiliary factor 38 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: U2af38provided by FlyBase
Official Full Name: U2 small nuclear riboprotein auxiliary factor 38provided by FlyBase
Primary source: FLYBASE:FBgn0017457
Locus tag: Dmel_CG3582
See related: AllianceGenome:FB:FBgn0017457
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3582; Dmel\CG3582; dU2AF38; DU2AF38; dU2AF[38]; l(2)06751; U2AF; U2AF 38; u2af38; U2AF38; Utaf38
Summary: Enables poly-pyrimidine tract binding activity. Involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Part of U2AF complex. Is expressed in embryonic brain; embryonic/larval brain; gonad; imaginal disc; and organism. Orthologous to human U2AF1 (U2 small nuclear RNA auxiliary factor 1) and U2AF1L4 (U2 small nuclear RNA auxiliary factor 1 like 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (292959..294681, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (292959..294681, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly-pyrimidine tract binding	IDA Inferred from Direct Assay more info	PubMed
enables pre-mRNA 3'-splice site binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of U2AF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U2AF complex	IDA Inferred from Direct Assay more info	PubMed
part_of U2AF complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IC Inferred by Curator more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

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