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Ets21C Ets at 21C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33229, updated on 10-May-2024

Summary

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Official Symbol
Ets21Cprovided by FlyBase
Official Full Name
Ets at 21Cprovided by FlyBase
Primary source
FLYBASE:FBgn0005660
Locus tag
Dmel_CG2914
See related
AllianceGenome:FB:FBgn0005660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2914; D-ets-6; D-Ets-6; D-Ets6; Dmel\CG2914; Ets; ets21c; ets21C; Ets21c; Ets6; ETS6
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in defense response to bacterium. Predicted to be active in nucleus. Is expressed in several structures, including extended germ band embryo; larval ventral nerve cord; presumptive embryonic/larval system; and spermatozoon. Human ortholog(s) of this gene implicated in blood platelet disease; myeloid leukemia; and thrombocytopenia. Orthologous to several human genes including ERG (ETS transcription factor ERG) and FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Ets21C in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (544925..552923, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (544925..552923, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lesswright Neighboring gene Signal peptide peptidase Neighboring gene nicotinic Acetylcholine Receptor beta3 Neighboring gene reduced mechanoreceptor potential A Neighboring gene uncharacterized nascent polypeptide-associated complex beta subunit Neighboring gene Translocator protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The transcription factor Ets21C drives tumor growth by cooperating with AP-1. Toggweiler J, et al. Sci Rep, 2016 Oct 7. PMID 27713480, Free PMC Article
  2. Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations. Hunt LC, et al. Genome Res, 2019 Aug. PMID 31249065, Free PMC Article
  3. Longevity is determined by ETS transcription factors in multiple tissues and diverse species. Dobson AJ, et al. PLoS Genet, 2019 Jul. PMID 31356597, Free PMC Article
  4. Isolation and characterization of five Drosophila genes that encode an ets-related DNA binding domain. Chen T, et al. Dev Biol, 1992 May. PMID 1577186
  5. A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8. Stanković D, et al. Dis Model Mech, 2020 Jun 26. PMID 32424050, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc.
    Title: Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc.
  2. Ets21c controls ISC proliferation as well as EC apoptosis through distinct sets of target genes that orchestrate cellular behaviors via intrinsic and non-autonomous signaling mechanisms.
    Title: Ets21c Governs Tissue Renewal, Stress Tolerance, and Aging in the Drosophila Intestine.
  3. Data show that Ets21C has a crucial role in the regulation of tumor growth as a loss of function critically reduced tumor growth, whereas an excess of Ets21C further increased tumor size. While Ets21C was shown only with a role in fine-tuning the transcriptional program of neoplastic tumors, results point towards a more fundamental role as activator of a specific set of target genes driving tumor growth and invasion.
    Title: The transcription factor Ets21C drives tumor growth by cooperating with AP-1.
  4. malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS-domain factor Ets21c and the nuclear receptor Ftz-F1, all acting downstream of Jun-N-terminal kinase.
    Title: Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.
  5. These studies identify Cic, Pnt, and Ets21C as critical downstream effectors of EGFR signaling in Drosophila Intestinal Stem Cells
    Title: EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ets at 21C
Names
CG2914-PA
CG2914-PB
CG2914-PC
CG2914-PD
Ets21C-PA
Ets21C-PB
Ets21C-PC
Ets21C-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    544925..552923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298618.1 → NP_001285547.1  Ets at 21C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285547.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29776, Q9VPQ9
    UniProtKB/TrEMBL
    A8E758
    Conserved Domains (2) summary
    cd08203
    Location:149 → 217
    SAM_PNT; Sterile alpha motif (SAM)/Pointed domain
    smart00413
    Location:254 → 339
    ETS; erythroblast transformation specific domain

  2. NM_001298619.1 → NP_001285548.1  Ets at 21C, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285548.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29776, Q9VPQ9
    UniProtKB/TrEMBL
    A8E758
    Conserved Domains (2) summary
    cd08203
    Location:149 → 217
    SAM_PNT; Sterile alpha motif (SAM)/Pointed domain
    smart00413
    Location:254 → 339
    ETS; erythroblast transformation specific domain

  3. NM_078721.2 → NP_523445.1  Ets at 21C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523445.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29776, Q9VPQ9
    UniProtKB/TrEMBL
    A8E758
    Related
    FBpp0077739
    Conserved Domains (2) summary
    cd08203
    Location:149 → 217
    SAM_PNT; Sterile alpha motif (SAM)/Pointed domain
    smart00413
    Location:254 → 339
    ETS; erythroblast transformation specific domain

  4. NM_001103577.3 → NP_001097047.1  Ets at 21C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097047.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYS7
    Conserved Domains (1) summary
    smart00413
    Location:84 → 169
    ETS; erythroblast transformation specific domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYS7 A8DYS7
A8E758 A8E758
P29776.2 P29776

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