U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ptth Prothoracicotropic hormone [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33238, updated on 10-May-2024

Summary

Go to the top of the page Help
Official Symbol
Ptthprovided by FlyBase
Official Full Name
Prothoracicotropic hormoneprovided by FlyBase
Primary source
FLYBASE:FBgn0013323
Locus tag
Dmel_CG13687
See related
AllianceGenome:FB:FBgn0013323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13687; Dmel\CG13687; ptth; PTTH
Summary
Enables prothoracicotrophic hormone activity. Involved in several processes, including negative phototaxis; positive regulation of ecdysteroid biosynthetic process; and torso signaling pathway. Located in varicosity. Is expressed in adult prothoracic gland innervating neuron PG-LP; prothoracic gland innervating neuron PG-LP; and prothoracic gland innervating neurons. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ptth in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (575711..576896, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (575711..576896, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Splicing factor 3b subunit 1 Neighboring gene Inositol phosphate kinase 2 Neighboring gene coiled Neighboring gene PvuII-PstI homology 13 Neighboring gene Goosecoid Neighboring gene long non-coding RNA:CR46148

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Protease cleavage at an engineered tetra-basic motif in Drosophila PTTH accelerates developmental timing. Shimell M, et al. MicroPubl Biol, 2019 Sep 26. PMID 32550412, Free PMC Article
  2. Purification and characterization of the prothoracicotropic hormone of Drosophila melanogaster. Kim AJ, et al. Proc Natl Acad Sci U S A, 1997 Feb 18. PMID 9037018, Free PMC Article
  3. Body size determination in insects: a review and synthesis of size- and brain-dependent and independent mechanisms. Callier V, et al. Biol Rev Camb Philos Soc, 2013 Nov. PMID 23521745
  4. Noggin proteins are multifunctional extracellular regulators of cell signaling. Karunaraj P, et al. Genetics, 2022 May 5. PMID 35357435, Free PMC Article
  5. Injury response checkpoint and developmental timing in insects. Hackney JF, et al. Fly (Austin), 2014. PMID 25833067, Free PMC Article

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ecdysone-dependent feedback regulation of prothoracicotropic hormone controls the timing of developmental maturation.
    Title: Ecdysone-dependent feedback regulation of prothoracicotropic hormone controls the timing of developmental maturation.
  2. PTTH signal contributes to coordination between environmental cues and the developmental program to ensure individual fitness and survival.
    Title: Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing.
  3. PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.
    Title: Neuroendocrine control of Drosophila larval light preference.
  4. study demonstrates that Torso, is the prothoracicotropic hormone (PTTH) receptor; study concludes that PTTH initiates metamorphosis by activation of the Torso/ERK pathway
    Title: The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables prothoracicotrophic hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prothoracicotrophic hormone activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in metamorphosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative phototaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ecdysteroid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in torso signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in torso signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in varicosity IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
prothoracicotropic hormone
Names
CG13687-PE
CG13687-PF
CG13687-PG
Ptth-PE
Ptth-PF
Ptth-PG
prothoracicotopic hormone

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    575711..576896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298621.1 → NP_001285550.1  prothoracicotropic hormone, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285550.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V5G9, X2JCX9
    Conserved Domains (1) summary
    pfam06083
    Location:148 → 216
    IL17; Interleukin-17

  2. NM_134693.3 → NP_608537.3  prothoracicotropic hormone, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608537.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V5G9, Q9VPR8
    Conserved Domains (1) summary
    pfam06083
    Location:122 → 190
    IL17; Interleukin-17

  3. NM_001316375.1 → NP_001303304.1  prothoracicotropic hormone, isoform G [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0WMK2, Q4V5G9
    Conserved Domains (1) summary
    pfam06083
    Location:114 → 182
    IL17; Interleukin-17
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WMK2 A0A0S0WMK2
Q24467 Q24467
Q9VPR8 Q9VPR8
X2JCX9 X2JCX9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous