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Dbp21E2 DEAD box protein 21E2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33254, updated on 10-May-2024

Summary

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Official Symbol
Dbp21E2provided by FlyBase
Official Full Name
DEAD box protein 21E2provided by FlyBase
Primary source
FLYBASE:FBgn0086130
Locus tag
Dmel_CG3561
See related
AllianceGenome:FB:FBgn0086130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg3561; CG3561; Dmel\CG3561; DmRH9; KH1
Summary
Predicted to enable helicase activity. Predicted to be involved in mitochondrial large ribosomal subunit assembly. Located in cytoplasm. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human DDX28 (DEAD-box helicase 28). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Dbp21E2 in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (811584..813380)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (811584..813380)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45259 Neighboring gene Nnf1b Neighboring gene SAGA factor-like TAF6 Neighboring gene Peroxin 12 Neighboring gene uncharacterized protein Neighboring gene Post-GPI attachment to proteins 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Nnf1 paralogs are partially redundant for somatic and germ line kinetochore function. Blattner AC, et al. Chromosoma, 2017 Feb. PMID 26892014
  2. A role for the cytoplasmic DEAD box helicase Dbp21E2 in rhodopsin maturation and photoreceptor viability. Hibbard KL, et al. J Neurogenet, 2012 Jun. PMID 22794106, Free PMC Article
  3. The SAGA core module is critical during Drosophila oogenesis and is broadly recruited to promoters. Soffers JHM, et al. PLoS Genet, 2021 Nov. PMID 34807910, Free PMC Article
  4. Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex. Aoki T, et al. Elife, 2012 Dec 13. PMID 23240086, Free PMC Article
  5. DDX56 Binds to Chikungunya Virus RNA To Control Infection. Taschuk F, et al. mBio, 2020 Oct 27. PMID 33109765, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial large ribosomal subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DEAD box protein 21E2
Names
CG3561-PA
Dbp21E2-PA
KH1
NP_608544.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    811584..813380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134700.4 → NP_608544.1  DEAD box protein 21E2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPT3
    Related
    FBpp0077674
    Conserved Domains (3) summary
    smart00487
    Location:126 → 330
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:343 → 462
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:113 → 314
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPT3 Q9VPT3

Gene LinkOut

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