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dock dreadlocks [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33262, updated on 10-May-2024

Summary

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Official Symbol
dockprovided by FlyBase
Official Full Name
dreadlocksprovided by FlyBase
Primary source
FLYBASE:FBgn0010583
Locus tag
Dmel_CG3727
See related
AllianceGenome:FB:FBgn0010583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2L19; CG3727; dck; Dm0447; Dmel\CG3727; doc; Dock; DOCK; l(2)04723; Nck
Summary
Enables several functions, including cell adhesion molecule binding activity; insulin receptor binding activity; and protein kinase binding activity. Involved in axon guidance; myoblast fusion; and negative regulation of insulin receptor signaling pathway. Located in several cellular components, including clathrin-coated vesicle; male germline ring canal; and nuclear body. Is expressed in several structures, including embryonic/larval brain; embryonic/larval gut; epidermis; extended germ band embryo; and presumptive embryonic/larval nervous system. Orthologous to human NCK1 (NCK adaptor protein 1) and NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See dock in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (825969..833241)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (825969..833241)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Clipper Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene drongo Neighboring gene long non-coding RNA:CR44060 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks. Dionne U, et al. Mol Cell, 2018 Jun 21. PMID 29910111, Free PMC Article
  2. Dissecting Nck/Dock signaling pathways in Drosophila visual system. Rao Y. Int J Biol Sci, 2005. PMID 15951852, Free PMC Article
  3. Domain requirements for the Dock adapter protein in growth- cone signaling. Rao Y, et al. Proc Natl Acad Sci U S A, 1998 Mar 3. PMID 9482841, Free PMC Article
  4. The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events. McCarty JH. Bioessays, 1998 Nov. PMID 9872057
  5. A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance. Clemens JC, et al. J Biol Chem, 1996 Jul 19. PMID 8663600

See all (154) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
    Title: Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants.
  2. Study propose that Dock links cell adhesion in FCs and FCMs with either Scar- or Vrp1-WASp-dependent Arp2/3 activation.
    Title: Dock mediates Scar- and WASp-dependent actin polymerization through interaction with cell adhesion molecules in founder cells and fusion-competent myoblasts.
  3. Data indicate that Activated Cdc42 kinase Ack forms a complex with dreadlocks via its SH2 domain.
    Title: Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis.
  4. Studies reveal for the first time that the adaptor protein Dock/Nck attenuates insulin signalling by recruiting PTP61F/PTP1B to its substrate, the IR.
    Title: Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.
  5. The Nck/Dock SH2/SH3 adapter protein plays a role in photoreceptor (R cell) axon guidance and target recognition in the Drosophila visual system.It mediates between cell surface receptors and the actin cytoskeleton. Review.
    Title: Dissecting Nck/Dock signaling pathways in Drosophila visual system.
  6. exogenous expression of mouse Dab1 causes tyrosine phosphorylation site-dependent morphology changes in the compound eye; phenotype enhanced by overexpression of the Nck protein Dock; suggests a conserved interaction between Disabled & Nck family members
    Title: Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons.
  7. Dock regulates olfactory axon pathfinding in Drosophila
    Title: Dock and Pak regulate olfactory axon pathfinding in Drosophila.
  8. Drosophila insulin receptor functions as a guidance receptor for the adapter protein Dock/Nck
    Title: Axons guided by insulin receptor in Drosophila visual system.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables insulin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dreadlocks
Names
CG3727-PA
CG3727-PB
CG3727-PC
CG3727-PD
dock
dock-PA
dock-PB
dock-PC
dock-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    825969..833241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057628.4 → NP_476976.1  dreadlocks, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476976.1

    Status: REVIEWED

    Related
    FBpp0077678
    Conserved Domains (4) summary
    cd09943
    Location:308 → 400
    SH2_Nck_family; Src homology 2 (SH2) domain found in the Nck family
    cd11765
    Location:16 → 66
    SH3_Nck_1; First Src Homology 3 domain of Nck adaptor proteins
    cd11766
    Location:118 → 170
    SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
    cd11767
    Location:190 → 245
    SH3_Nck_3; Third Src Homology 3 domain of Nck adaptor proteins

  2. NM_164389.2 → NP_722657.1  dreadlocks, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722657.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24218, Q8IPW2, Q9VPU1
    Related
    FBpp0077679
    Conserved Domains (4) summary
    cd09943
    Location:446 → 538
    SH2_Nck_family; Src homology 2 (SH2) domain found in the Nck family
    cd11765
    Location:154 → 204
    SH3_Nck_1; First Src Homology 3 domain of Nck adaptor proteins
    cd11766
    Location:256 → 308
    SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
    cd11767
    Location:328 → 383
    SH3_Nck_3; Third Src Homology 3 domain of Nck adaptor proteins

  3. NM_164390.2 → NP_722658.1  dreadlocks, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722658.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24218, Q8IPW2, Q9VPU1
    Related
    FBpp0077680
    Conserved Domains (4) summary
    cd09943
    Location:446 → 538
    SH2_Nck_family; Src homology 2 (SH2) domain found in the Nck family
    cd11765
    Location:154 → 204
    SH3_Nck_1; First Src Homology 3 domain of Nck adaptor proteins
    cd11766
    Location:256 → 308
    SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
    cd11767
    Location:328 → 383
    SH3_Nck_3; Third Src Homology 3 domain of Nck adaptor proteins

  4. NM_001272916.1 → NP_001259845.1  dreadlocks, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259845.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24218, Q8IPW2, Q9VPU1
    Conserved Domains (4) summary
    cd09943
    Location:446 → 538
    SH2_Nck_family; Src homology 2 (SH2) domain found in the Nck family
    cd11765
    Location:154 → 204
    SH3_Nck_1; First Src Homology 3 domain of Nck adaptor proteins
    cd11766
    Location:256 → 308
    SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
    cd11767
    Location:328 → 383
    SH3_Nck_3; Third Src Homology 3 domain of Nck adaptor proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24218 Q24218
Q8IPW2 Q8IPW2
Q9VPU1 Q9VPU1

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