U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dbe dribble [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33269, updated on 10-May-2024

Summary

Go to the top of the page Help
Official Symbol
dbeprovided by FlyBase
Official Full Name
dribbleprovided by FlyBase
Primary source
FLYBASE:FBgn0020305
Locus tag
Dmel_CG4258
See related
AllianceGenome:FB:FBgn0020305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4258; DBE; Dmel\CG4258; l(2)k05428; l(2)k06708
Summary
Predicted to enable RNA binding activity. Involved in rRNA processing. Located in nucleolus and nucleoplasm. Is expressed in several structures, including anterior endoderm anlage; egg chamber; embryonic/larval midgut primordium; embryonic/larval visceral muscle cell; and germ layer. Orthologous to human KRR1 (KRR1 small subunit processome component homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See dbe in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (868673..869857, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (868673..869857, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene arouser Neighboring gene Phosphatase 1 nuclear targeting subunit Neighboring gene uncharacterized protein Neighboring gene neither inactivation nor afterpotential A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Gene drive that results in addiction to a temperature-sensitive version of an essential gene triggers population collapse in Drosophila. Oberhofer G, et al. Proc Natl Acad Sci U S A, 2021 Dec 7. PMID 34845012, Free PMC Article
  2. Crystallization and preliminary crystallographic analysis of the central domain of Drosophila Dribble, a protein that is essential for ribosome biogenesis. Cheng TC, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 May 1. PMID 20445256, Free PMC Article
  3. Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble. Yiu CP, et al. Biochem Biophys Res Commun, 2006 Apr 28. PMID 16542639
  4. Identification and characterization of kraken, a gene encoding a putative hydrolytic enzyme in Drosophila melanogaster. Edwin Chan HY, et al. Gene, 1998 Nov 19. PMID 9831651
  5. Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing. Chan HY, et al. Mol Biol Cell, 2001 May. PMID 11359931, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystals of DBE(16-197) were grown by the sitting-drop vapour-diffusion method at 289 K using ammonium phosphate as a precipitant.
    Title: Crystallization and preliminary crystallographic analysis of the central domain of Drosophila Dribble, a protein that is essential for ribosome biogenesis.
  2. The presence of structural disorder is an important feature of DBE that facilitates the protein to interact with RNAs in the nucleolus.
    Title: Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dribble
Names
CG4258-PA
dbe-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    868673..869857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057892.4 → NP_477240.1  dribble [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477240.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02394, Q9VPU8
    Related
    FBpp0077694
    Conserved Domains (2) summary
    smart00322
    Location:140 → 190
    KH; K homology RNA-binding domain
    COG1094
    Location:34 → 212
    Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPU8.1 Q9VPU8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous