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PNUTS Phosphatase 1 nuclear targeting subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33270, updated on 10-May-2024

Summary

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Official Symbol
PNUTSprovided by FlyBase
Official Full Name
Phosphatase 1 nuclear targeting subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0053526
Locus tag
Dmel_CG33526
See related
AllianceGenome:FB:FBgn0053526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31657; CG33526; CG4124; Dmel\CG33526; pnuts; Pnuts; PNUTS-RB; PNUTSDm
Summary
Enables protein phosphatase 1 binding activity. Involved in developmental growth and gene expression. Predicted to be located in nucleus. Is expressed in several structures, including germ band; larval ventral nerve cord; and presumptive embryonic/larval system. Orthologous to human PPP1R10 (protein phosphatase 1 regulatory subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See PNUTS in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (870465..877038)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (870465..877038)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene arouser Neighboring gene dribble Neighboring gene uncharacterized protein Neighboring gene neither inactivation nor afterpotential A Neighboring gene long non-coding RNA:CR45348

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing. Chan HY, et al. Mol Biol Cell, 2001 May. PMID 11359931, Free PMC Article
  2. A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons. Morton DJ, et al. PLoS Genet, 2020 Jul. PMID 32645003, Free PMC Article
  3. SR proteins control a complex network of RNA-processing events. Bradley T, et al. RNA, 2015 Jan. PMID 25414008, Free PMC Article
  4. PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth. Ciurciu A, et al. PLoS Genet, 2013 Oct. PMID 24204300, Free PMC Article
  5. A genetic screen for olfactory habituation mutations in Drosophila: analysis of novel foraging alleles and an underlying neural circuit. Eddison M, et al. PLoS One, 2012. PMID 23284741, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatase 1 nuclear targeting subunit
Names
CG33526-PA
CG33526-PB
CG33526-PD
CG33526-PE
PNUTS-PA
PNUTS-PB
PNUTS-PD
PNUTS-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    870465..877038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014453.2 → NP_001014453.1  phosphatase 1 nuclear targeting subunit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014453.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q70HU3, Q7KU01
    Conserved Domains (2) summary
    smart00356
    Location:1110 → 1130
    ZnF_C3H1; zinc finger
    pfam08711
    Location:92 → 142
    Med26; TFIIS helical bundle-like domain

  2. NM_001272921.1 → NP_001259850.1  phosphatase 1 nuclear targeting subunit, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259850.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q70HU3, Q7KU01
    Conserved Domains (2) summary
    smart00356
    Location:1110 → 1130
    ZnF_C3H1; zinc finger
    pfam08711
    Location:92 → 142
    Med26; TFIIS helical bundle-like domain

  3. NM_001014455.2 → NP_001014455.1  phosphatase 1 nuclear targeting subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014455.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q70HU2, Q95R52, Q9VPU9
    Conserved Domains (1) summary
    PTZ00449
    Location:425 → 570
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

  4. NM_001014454.2 → NP_001014454.1  phosphatase 1 nuclear targeting subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014454.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q70HU2, Q95R52, Q9VPU9
    Conserved Domains (1) summary
    PTZ00449
    Location:425 → 570
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q70HU2 Q70HU2
Q70HU3 Q70HU3
Q7KU01 Q7KU01
Q960J4 Q960J4
Q9VPU9 Q9VPU9

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