ninaA neither inactivation nor afterpotential A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ninaAprovided by FlyBase
Official Full Name: neither inactivation nor afterpotential Aprovided by FlyBase
Primary source: FLYBASE:FBgn0002936
Locus tag: Dmel_CG3966
See related: AllianceGenome:FB:FBgn0002936
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3966; Dmel\CG3966; ninA; NinaA; NINAA
Summary: Enables cyclosporin A binding activity. Involved in glycoprotein metabolic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and rhodopsin biosynthetic process. Located in cytoplasmic vesicle and endoplasmic reticulum lumen. Is integral component of endoplasmic reticulum membrane. Is expressed in Bolwig organ; adult head; and eye. Orthologous to human PPIC (peptidylprolyl isomerase C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (877302..878270)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (877302..878270)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cyclosporin A binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclosporin A binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' protein folding	TAS Traceable Author Statement more info	PubMed
involved_in N-glycan processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deglycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein peptidyl-prolyl isomerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhodopsin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in rhodopsin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG3966-PA; either inactivation nor afterpotential A; neither inactivation nor after potential; ninaA-PA

NP_476656.1

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