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Tango14 Transport and Golgi organization 14 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33298, updated on 10-May-2024

Summary

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Official Symbol
Tango14provided by FlyBase
Official Full Name
Transport and Golgi organization 14provided by FlyBase
Primary source
FLYBASE:FBgn0031312
Locus tag
Dmel_CG4775
See related
AllianceGenome:FB:FBgn0031312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:SD10843; CG4775; Dmel\CG4775; l(2)k00619; Tango 14; TANGO14
Summary
Predicted to contribute to dehydrodolichyl diphosphate synthase activity. Involved in protein secretion. Located in endoplasmic reticulum. Is expressed in adult head. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Tango14 in Genome Data Viewer
Location:
21F1-21F1; 2-2 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1158661..1160220)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1158661..1160220)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lethal (2) 10685 Neighboring gene Transcription factor B4 Neighboring gene Vacuolar protein sorting 29 Neighboring gene capulet Neighboring gene antisense RNA:CR43767 Neighboring gene uncharacterized protein Neighboring gene Integrator 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of Drosophila NUS1 results in cholesterol accumulation and Parkinson's disease-related neurodegeneration. Xue J, et al. FASEB J, 2022 Jul. PMID 35695805
  2. Coding mutations in NUS1 contribute to Parkinson's disease. Guo JF, et al. Proc Natl Acad Sci U S A, 2018 Nov 6. PMID 30348779, Free PMC Article
  3. An Efficient Screen for Cell-Intrinsic Factors Identifies the Chaperonin CCT and Multiple Conserved Mechanisms as Mediating Dendrite Morphogenesis. Wang YH, et al. Front Cell Neurosci, 2020. PMID 33100975, Free PMC Article
  4. Transcriptional regulation by CHIP/LDB complexes. Bronstein R, et al. PLoS Genet, 2010 Aug 12. PMID 20730086, Free PMC Article
  5. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to dehydrodolichyl diphosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dolichol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dolichol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of dehydrodolichyl diphosphate synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dehydrodolichyl diphosphate synthase complex IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transport and golgi organization 14
Names
CG4775-PA
CG4775-PB
Tango14-PA
Tango14-PB
lethal (2) k00619
NP_001259857.1
NP_608577.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1158661..1160220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134733.3 → NP_608577.2  transport and golgi organization 14, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608577.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPX8
    Related
    FBpp0077626
    Conserved Domains (1) summary
    cl00230
    Location:78 → 277
    Cis_IPPS; Cis (Z)-Isoprenyl Diphosphate Synthases

  2. NM_001272928.1 → NP_001259857.1  transport and golgi organization 14, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259857.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPX8
    Conserved Domains (1) summary
    cl00230
    Location:78 → 277
    Cis_IPPS; Cis (Z)-Isoprenyl Diphosphate Synthases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95R38 Q95R38
Q9VPX8 Q9VPX8

Gene LinkOut

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