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Kcp kielin/chordin-like protein [ Mus musculus (house mouse) ]

Gene ID: 333088, updated on 11-Apr-2024

Summary

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Official Symbol
Kcpprovided by MGI
Official Full Name
kielin/chordin-like proteinprovided by MGI
Primary source
MGI:MGI:2141640
See related
Ensembl:ENSMUSG00000059022 AllianceGenome:MGI:2141640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crim2; Gm793; KCP-1; CRIM-2
Summary
Acts upstream of or within hematopoietic progenitor cell differentiation and positive regulation of BMP signaling pathway. Located in extracellular space. Orthologous to human KCP (kielin cysteine rich BMP regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 11.6), ovary adult (RPKM 5.1) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.3; 6 12.36 cM
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29473161..29508006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29473162..29508003, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene filamin C, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr6:29417613-29417914 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit F Neighboring gene sperm microtubule inner protein 1 Neighboring gene predicted gene, 26627 Neighboring gene STARR-positive B cell enhancer ABC_E3647 Neighboring gene STARR-seq mESC enhancer starr_15441 Neighboring gene interferon regulatory factor 5 Neighboring gene transportin 3 Neighboring gene STARR-seq mESC enhancer starr_15442 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29559591-29559700 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29559883-29560036 Neighboring gene STARR-seq mESC enhancer starr_15443 Neighboring gene STARR-seq mESC enhancer starr_15447 Neighboring gene STARR-positive B cell enhancer ABC_E6419 Neighboring gene STARR-seq mESC enhancer starr_15449 Neighboring gene predicted gene, 30896

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice. Soofi A, et al. J Biol Chem, 2017 Jun 2. PMID 28424263, Free PMC Article
  2. The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice. Soofi A, et al. Am J Physiol Gastrointest Liver Physiol, 2016 Oct 1. PMID 27514479, Free PMC Article
  3. Kielin/chordin-like protein attenuates both acute and chronic renal injury. Soofi A, et al. J Am Soc Nephrol, 2013 May. PMID 23539757, Free PMC Article
  4. The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia. Lin J, et al. Mol Cell Biol, 2006 Jun. PMID 16738323, Free PMC Article
  5. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Lin J, et al. Nat Med, 2005 Apr. PMID 15793581

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kielin/chordin-like protein deficiency aggravates pressure overload-induced cardiac dysfunction and remodeling via P53/P21/CCNB1 signaling in mice.
    Title: Kielin/chordin-like protein deficiency aggravates pressure overload-induced cardiac dysfunction and remodeling via P53/P21/CCNB1 signaling in mice.
  2. Kielin/chordin-like protein deficiency causes cardiac aging in male mice.
    Title: Kielin/chordin-like protein deficiency causes cardiac aging in male mice.
  3. Metabolic profiling indicated increased energy expenditure in KCP-overexpressing mice and reduced expenditure in the KCP mutants with no effect on food intake or activity. These findings demonstrate that shifting the TGF-beta superfamily signaling with a secreted protein can alter the physiology and thermogenic properties of adipose tissue to reduce obesity even when mice are fed a high-fat diet.
    Title: The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice.
  4. These data suggest that extracellular regulation of the TGF-beta/BMP signaling axis by KCP, and by extension possibly other cysteine-rich domain proteins, can attenuate both acute and chronic renal injury.
    Title: Kielin/chordin-like protein attenuates both acute and chronic renal injury.
  5. role for KCP in modulating the responses between these anti- and profibrotic cytokines in the initiation and progression of renal interstitial fibrosis
    Title: The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia.
  6. The data indicate an important role for KCP in attenuating the pathology of renal fibrotic disease.
    Title: Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kielin/chordin-like protein
Names
cysteine rich BMP regulator 2 (chordin like)
cysteine-rich BMP regulator 2
cysteine-rich motor neuron 2 protein
kielin/chordin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029985.4 → NP_001025156.3  kielin/chordin-like protein precursor

    See identical proteins and their annotated locations for NP_001025156.3

    Status: VALIDATED

    Source sequence(s)
    AC079276, BC059023
    Consensus CDS
    CCDS57415.1
    UniProtKB/Swiss-Prot
    E9QJU0, Q3U492, Q56NI8
    UniProtKB/TrEMBL
    E9QNB3
    Related
    ENSMUSP00000099135.4, ENSMUST00000101614.10
    Conserved Domains (5) summary
    pfam00093
    Location:136 → 190
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1214 → 1363
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:1489 → 1542
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1407 → 1478
    C8; C8 domain
    cl17735
    Location:428 → 484
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29473161..29508006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241070.4 → XP_011239372.1  kielin/chordin-like protein isoform X8

    Conserved Domains (6) summary
    smart00214
    Location:1221 → 1278
    VWC; von Willebrand factor (vWF) type C domain
    pfam00093
    Location:166 → 220
    VWC; von Willebrand factor type C domain
    cl17735
    Location:634 → 690
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1285 → 1432
    VWD; von Willebrand factor type D domain
    pfam03157
    Location:1757 → 1975
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam08742
    Location:1482 → 1549
    C8; C8 domain

  2. XM_011241071.3 → XP_011239373.1  kielin/chordin-like protein isoform X1

    Conserved Domains (5) summary
    pfam00093
    Location:166 → 220
    VWC; von Willebrand factor type C domain
    cl17735
    Location:458 → 514
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1285 → 1432
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:1560 → 1613
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1482 → 1549
    C8; C8 domain

  3. XM_017321660.3 → XP_017177149.1  kielin/chordin-like protein isoform X2

    Conserved Domains (5) summary
    pfam00093
    Location:136 → 190
    VWC; von Willebrand factor type C domain
    cl17735
    Location:428 → 484
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1255 → 1402
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:1530 → 1583
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1452 → 1519
    C8; C8 domain

  4. XM_017321661.3 → XP_017177150.1  kielin/chordin-like protein isoform X4

    Conserved Domains (5) summary
    pfam00093
    Location:166 → 220
    VWC; von Willebrand factor type C domain
    cl17735
    Location:458 → 514
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1243 → 1390
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:1518 → 1571
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1440 → 1507
    C8; C8 domain

  5. XM_006505131.4 → XP_006505194.1  kielin/chordin-like protein isoform X3

    Conserved Domains (5) summary
    pfam00093
    Location:166 → 220
    VWC; von Willebrand factor type C domain
    cl17735
    Location:458 → 514
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1244 → 1391
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:1519 → 1572
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1441 → 1508
    C8; C8 domain

  6. XM_030255489.2 → XP_030111349.1  kielin/chordin-like protein isoform X6

    Conserved Domains (5) summary
    smart00214
    Location:845 → 902
    VWC; von Willebrand factor (vWF) type C domain
    cl17735
    Location:82 → 138
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:909 → 1056
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:1184 → 1237
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1106 → 1173
    C8; C8 domain

  7. XM_017321663.3 → XP_017177152.1  kielin/chordin-like protein isoform X5

    Conserved Domains (4) summary
    cl17735
    Location:277 → 333
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1104 → 1251
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:1379 → 1432
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1301 → 1368
    C8; C8 domain

  8. XM_006505134.5 → XP_006505197.1  kielin/chordin-like protein isoform X7

    Conserved Domains (1) summary
    cl17735
    Location:166 → 220
    VWC; von Willebrand factor type C domain

RNA

  1. XR_868761.4 RNA Sequence

  2. XR_003956221.2 RNA Sequence

  3. XR_003956220.2 RNA Sequence

  4. XR_003956222.2 RNA Sequence

    Related
    ENSMUST00000091391.11

  5. XR_004942978.1 RNA Sequence

  6. XR_868762.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U492.2 GenPept UniProtKB/Swiss-Prot:Q3U492

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