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ap2b1 adaptor related protein complex 2 subunit beta 1 [ Danio rerio (zebrafish) ]

Gene ID: 334632, updated on 27-Mar-2024

Summary

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Official Symbol
ap2b1provided by ZNC
Official Full Name
adaptor related protein complex 2 subunit beta 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6564
See related
Ensembl:ENSDARG00000035152 AllianceGenome:ZFIN:ZDB-GENE-030131-6564
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa16e07; zgc:55659; wu:fa16c06; wu:fa16e07; wu:fc18c08
Summary
Predicted to enable clathrin binding activity. Predicted to be involved in vesicle-mediated transport. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in membrane. Predicted to be part of clathrin adaptor complex. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ap2b1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (61657733..61724086)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (60973012..61039365)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene draculin-like, tandem duplicate 1 Neighboring gene draculin Neighboring gene ras-like protein family member 10B Neighboring gene growth arrest specific 2 like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Umasankar PK, et al. Nat Cell Biol, 2012 Apr 8. PMID 22484487, Free PMC Article
  2. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
  3. Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Mishima Y, et al. Genes Dev, 2009 Mar 1. PMID 19240126, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AP-2 complex subunit beta
Names
adaptor-related protein complex 2, beta 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199919.2 → NP_956213.2  AP-2 complex subunit beta

    See identical proteins and their annotated locations for NP_956213.2

    Status: PROVISIONAL

    Source sequence(s)
    BC066566
    UniProtKB/TrEMBL
    A0A0R4IC49, A0A8M1PAE5, B0R152, Q6NYJ9
    Related
    ENSDARP00000132587.2, ENSDART00000171248.2
    Conserved Domains (5) summary
    smart00809
    Location:731 → 831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840 → 950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region
    pfam12717
    Location:99 → 268
    Cnd1; non-SMC mitotic condensation complex subunit 1
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    61657733..61724086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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