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SerRS Seryl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33518, updated on 10-May-2024

Summary

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Official Symbol
SerRSprovided by FlyBase
Official Full Name
Seryl-tRNA synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0031497
Locus tag
Dmel_CG17259
See related
AllianceGenome:FB:FBgn0031497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17259; Dmel\CG17259; DmSRS1
Summary
Enables ATP binding activity. Predicted to be involved in seryl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See SerRS in Genome Data Viewer
Location:
23C5-23C5; 2-8 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3035493..3037403, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3035493..3037403, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44147 Neighboring gene beta4GalNAcTB pilot Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cornichon related Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function. Guitart T, et al. J Biol Chem, 2010 Dec 3. PMID 20870726, Free PMC Article
  2. Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit. Picchioni D, et al. Cell Rep, 2019 Apr 2. PMID 30943413
  3. Small chaperons and autophagy protected neurons from necrotic cell death. Lei Y, et al. Sci Rep, 2017 Jul 18. PMID 28720827, Free PMC Article
  4. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
  5. A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis. Ables ET, et al. G3 (Bethesda), 2016 Aug 9. PMID 27226164, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in seryl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in seryl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Seryl-tRNA synthetase
Names
CG17259-PA
CG17259-PB
SerRS-PA
SerRS-PB
seryl-tRNA synthetase
NP_001259982.1
NP_608743.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3035493..3037403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134899.3 → NP_608743.2  Seryl-tRNA synthetase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608743.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQL1
    Related
    FBpp0077351
    Conserved Domains (3) summary
    PLN02678
    Location:3 → 476
    PLN02678; seryl-tRNA synthetase
    cd00770
    Location:153 → 461
    SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
    pfam02403
    Location:3 → 111
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

  2. NM_001273053.1 → NP_001259982.1  Seryl-tRNA synthetase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259982.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQL1
    Conserved Domains (3) summary
    PLN02678
    Location:3 → 476
    PLN02678; seryl-tRNA synthetase
    cd00770
    Location:153 → 461
    SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
    pfam02403
    Location:3 → 111
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TC0 Q95TC0
Q9VQL1 Q9VQL1

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